Linköping University Hospital

Optimal cord blood vitamin D concentration does not protect against type 1 diabetes: a longitudinal cohort study

Abstract Calcidiol (25-hydroxy vitamin D [25(OH)D]) has a putative role in protection against auto-immune diseases, including type 1 diabetes (T1D). However, contradictory findings have been reported. We compared concentrations of the 25(OH)D in cord-blood in 83 children who late...

Probiotics and Risk of Death, Necrotizing Enterocolitis, and Sepsis in Very Preterm Infants

Importance Probiotics are reported to benefit preterm infants, but population-based clinical evidence is limited. In 2020, the Swedish Neonatal Society issued a national recommendation to supplement very preterm infants (28 weeks 0 days’ to 31 weeks 6 days’ gestation) with probio...

Health-related quality of life, psychological well-being and physical activity in patients with mild-to-moderate ascending aortic dilation - a cross-sectional case-control study

Abstract Aim To investigate health-related quality of life (HRQoL), psychological well-being and physical activity in patients with mild-to-moderate ascending aortic dilation. Background While ascending aortic dilation often require lifelong surveillance due to the increased risk...

Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease

BACKGROUND: Beta-blockers may improve outcomes in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease, but randomized trials have been inconclusive. METHODS: This was a multicenter, open-label, pragmatic, phase 4 randomized trial. Patients 40...

Sodium supplementation strategies in preterm infants: effects on growth, electrolyte balance, and exploratory evidence on neurodevelopment — a systematic review and meta-analysis

This study evaluated the effects of sodium supplementation on growth, electrolyte balance, and neurodevelopmental outcomes in preterm infants. A systematic review and meta-analysis of published studies were conducted using data from PubMed, Embase, Scopus, and Google Scholar, inc...

Food choices and beliefs in adults with inflammatory bowel disease in Sweden

Abstract Objectives Diet is a recognised risk factor for inflammatory bowel disease (IBD) and a management strategy. Concerns persist regarding the adverse effects of restrictive diets, including nutritional deficiencies and selective eating. The impact of IBD on patients’ belief...

Low-Voltage Ablation in Persistent Atrial Fibrillation

Importance Pulmonary vein isolation remains the foundational ablation approach for atrial fibrillation (AF), yet outcomes in persistent AF remain suboptimal. Targeting low-voltage zones identified by electroanatomical mapping offers a promising strategy for enhancing ablation suc...

Adaptation of the molecular bacterial load assay for real-time quantification of Mycobacterium tuberculosis in the clinical routine laboratory

ABSTRACT Rapid quantification of Mycobacterium tuberculosis (Mtb) is important for monitoring bacterial load during treatment and in clinical studies. The molecular bacterial load assay detecting Mtb 16S ribosomal RNA (TB-MBLA) can quantify mycobacterial load within hours. As the...

Trajectories of refraction and strabismus from 2.5 to 12 years in a national cohort of extremely preterm children‐ the Extremely Preterm Infants in Sweden Study (EXPRESS)

Abstract Purpose To investigate the longitudinal development of refraction and strabismus in a national cohort of children born extremely preterm (EPT) and find relations to perinatal events and neurodevelopmental outcomes. Methods All surviving children born <27‐gestation wee...

Correlations between monitor alarm workload and overall workload in Swedish emergency departments: a prospective multicenter cross-sectional study

<title>Abstract</title> Background Emergency departments (ED) operate under conditions of high clinical demands, time-critical decisions and tasks. These characteristics can result in substantial workload on staff, which increases the risk of diagnostic errors and procedural dela...

Physician-Modified Cook Zenith Alpha Thoracic Endovascular Graft with Preservation of Active Fixation Barbs: A Step-by-Step Technical Guide

Physician-modified endografts (PMEGs) represent an important treatment option for urgent and semi-urgent complex abdominal aortic aneurysms (cAAAs). The Zenith Alpha Thoracic Endovascular Graft (Cook Medical, Bloomington, IN, USA) is a common choice for PMEGs due to its low strut...

Associations between organizational readiness and implementation fidelity in national implementation of WHO’s labour care guide in Sweden: a prospective observational study

Abstract Background During 2024 and 2025, an adapted version of the World Health Organization’s Labour Care Guide was implemented in approximately half of Sweden’s labor wards within the PICRINO trial. Organizational readiness is widely regarded as a key determinant of successful...

Impact of intraoperative CT on implant accuracy and reoperation rates in orbital floor reconstruction

BACKGROUND: Implant malposition is a leading cause of reoperation after orbital floor reconstruction. Intraoperative computed tomography (CT) enables immediate assessment and correction, however its impact on implant positioning accuracy and outcomes remains insufficiently studie...