Life Science Zurich

An automated high-resolution screening platform identifies regulators of anchor cell invasion in C. elegans

Microfluidic devices are valuable tools for live imaging. However, widespread adoption of microfluidic-based screening methods has been limited by the complexity of the existing techniques. Here, we introduce a user-friendly, high-throughput, and high-resolution automated imaging...

Multiplexed embryo profiling links cellular state to zygotic genome activation in single cells

Abstract Multicellular self-organization depends on interactions across multiple length scales, yet mapping protein states at high spatial resolution in whole-mount embryos remains challenging. Here, we introduce high-throughput 3D in toto iterative immunofluorescence imaging (3D...