Liaoning Provincial People's Hospital

AI-Driven precision targeted therapy for EGFR-mutant non-small cell lung cancer: From therapeutic evolution and resistance mechanisms to intelligent decision systems

ObjectiveTo critically review the current pharmacologic treatment landscape for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC), focusing on clinical pharmacology, therapeutic evolution, and emerging challenges of EGFR-targeted therapies.Data Sou...

Physiological Occlusal Force Promotes Heme Oxygenase-1 to Repair Periodontal Injury in a Rat Model of Replanted Teeth

Objective The physiological occlusal force generated by mastication plays a critical role in tooth replantation after complete avulsion by promoting periodontal ligament healing. Heme oxygenase-1 (HO-1), a classical cytoprotective factor, exhibits mechanoresponsive expression in...