Liaocheng People's Hospital

Targeting an IL-17/IL-36 pathogenic hub in hidradenitis suppurativa with a bispecific antibody

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with a high unmet need, particularly for treatment-resistant tunnels. Integrated multiomics analysis revealed that HS tunnels are spatially organized, self-amplifying inflammatory circuits driven by synergistic...

Association between respiratory phenotypes and successful ventilator liberation in early-onset and late-onset ARDS: a multicenter cohort study

Early-onset and late-onset acute respiratory distress syndrome (ARDS) differ in clinical course and outcomes, but their longitudinal respiratory trajectories remain unclear. We aimed to characterize respiratory trajectories in early- and late-onset ARDS and identify trajectory-ba...

Ultrasonographic Diagnosis of Acute Gallbladder Torsion in a Child: A Case Report

ABSTRACT Gallbladder torsion is an extremely rare condition in the pediatric population. A 32‐month‐old boy presented with paroxysmal abdominal pain and vomiting. An initial dedicated intestinal ultrasonography yielded false‐negative results, and conservative treatment failed to...

Recent advances in Ganoderma lucidum-derived bioactive components for cancer therapy

Abstract Ganoderma lucidum has attracted increasing attention in cancer research because of its diverse bioactive components and immunomodulatory properties. However, its antitumor effects are often discussed as broad “anticancer activity”, which may obscure the distinct roles of...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Water hardness and all-cause and cause-specific mortality: evidence from a prospective cohort study

The health implications of domestic water hardness remain controversial, with limited prospective evidence on cause-specific mortality. We investigated associations of calcium carbonate (CaCO 3 ), calcium (Ca), and magnesium (Mg) concentrations with all-cause and cause-specific m...

Short-chain fatty acids as key mediators of the microbiota–gut–brain axis in chronic cerebral hypoperfusion: mechanisms and therapeutic

Abstract Chronic cerebral hypoperfusion (CCH) is an important contributor to vascular cognitive impairment and neurodegenerative disorders, characterized by neuronal injury, blood–brain barrier (BBB) disruption, neuroinflammation, mitochondrial dysfunction, and synaptic impairmen...

Bilateral internal carotid artery dissection and occlusion in Eagle syndrome treated with emergency single-session bilateral carotid artery stenting: a case report

Eagle syndrome (stylocarotid variant) is a rare but potentially life-threatening cause of internal carotid artery (ICA) dissection and ischemic stroke. Bilateral ICA dissection due to Eagle syndrome has been treated with both staged and single-session bilateral carotid stenting e...

Intrathyroidal thymic carcinoma with delayed cervical lymph node metastasis 5 years postoperatively: a case report with focus on ultrasonic features

Intrathyroidal thymic carcinoma (ITTC) is a rare thyroid malignancy with nonspecific imaging features. The ultrasonographic characteristics of its metastatic lymph nodes, particularly in cases of delayed metastasis, remain poorly understood. To report a case of ITTC with cervical...

Prognostic value of RDW and its derivatives in ICU patients with hypertensive chronic kidney disease

Chronic kidney disease (CKD) complicated with hypertension constitutes a major global public health burden. Early identification of reliable prognostic biomarkers is essential to optimize clinical management and reduce mortality among these patients. A total of 6,731 intensive ca...

Age-Associated Patterns of Cardiovascular Risk and Disease Phenotypes Across Diverse Care Settings: The GLOB-cAGE Consortium

Reported prevalence of cardiovascular disease (CVD) risk factors and phenotypes varies widely. In multi-cohort analyses, such variation reflects population risk, care setting, and data capture. We harmonized baseline data from four analytic cohorts (N=54,188, aged ≥50 years) in f...

Single-session therapeutic plasma exchange as salvage therapy for pegaspargase-induced severe acute pancreatitis accompanied by multiple organ dysfunction in a pediatric patient with B-cell precursor acute lymphoblastic leukemia: a case report

Abstract Background Pegaspargase-related severe acute pancreatitis (SAP) combined with persistent multiple organ dysfunction syndrome (MODS) is a life-threatening adverse reaction in children receiving acute lymphoblastic leukemia (ALL) chemotherapy. Standard intensive supportive...