Lianyungang Oriental Hospital

The CARM1–YIPF2 axis drives breast cancer progression and predicts poor prognosis

Objective To investigate the roles of CARM1 and its regulatory effect on YIPF2 in breast cancer progression. Methods Breast cancer cells were transfected with CARM1 siRNA to knock down CARM1 expression. Cell proliferation, apoptosis, migration, and invasion were assessed using Ed...

Morphologic and hemodynamic risk factors for paraophthalmic segment aneurysm rupture

To evaluate the impact of morphologic and hemodynamic characteristics on paraophthalmic segment aneurysms (PSAs) with the goal of identifying reliable risk factors for PSAs rupture. A case-control study was conducted among patients with a newly diagnosed PSAs who were treated at...

Neutrophil to lymphocyte ratio at stoma site predicts colorectal cancer prognosis

This research examines the connection between the neutrophil-to-lymphocyte ratio (NLR) observed at the stoma site and the prognostic outcomes in patients with colorectal cancer, in comparison to individuals without cancer. By conducting a retrospective analysis of clinical record...

Application effect of PBL combined with skeletal simulation-based surgical training teaching mode in orthopedic teaching

Orthopedics is a highly practical clinical discipline, and traditional single problem-based learning (PBL) teaching is limited by the lack of intuitive operational training, which easily leads to the disconnection between theoretical learning and clinical practice in medical stud...

Band-like marginal gingival necrosis as the initial manifestation of acute monocytic leukemia: a case report

Oral manifestations may precede the diagnosis of acute myeloid leukemia (AML), particularly in monocytic subtypes, but the typical findings are gingival enlargement, spontaneous bleeding, petechiae, or nonspecific ulceration. Band-like necrosis confined to the gingival margins an...

Comparative influence of opioid-free versus opioid-containing anesthetic techniques upon Th1/Th2 balance during laparoscopic colorectal cancer procedures: a randomized controlled trial

Abstract Background Surgical resection is central to colorectal cancer management, but surgery and anesthesia can induce perioperative immunosuppression. Opioids, a mainstay of perioperative analgesia, may impair cellular immunity, including disruption of Th1/Th2 immune equilibri...

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

ABSTRACT Chimeric antigen receptor (CAR)‐engineered cell therapies are being extended from hematological malignancies to autoimmune, inflammatory, and fibrotic diseases, although the maturity of evidence differs markedly among platforms and indications. Early clinical evidence fr...

Discovery of a novel MurA inhibitor via AlphaFold 3 model-based virtual screening

S. aureus is one of the most important bacteria associated with human diseases. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in the synthesis of peptidoglycan in bacterial cell walls. The crystal structure of MurA from S. aureus has...

A three-metabolite microbiota-associated signature for early risk stratification of gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes and long-term metabolic and cardiovascular risk. However, oral glucose tolerance testing at 24–28 gestational weeks limits early risk stratification. Gut microbiota-associated metabolites may reflec...

Stress hyperglycaemic ratio is independently associated with intramyocardial haemorrhage in STEMI patients: a cardiac magnetic resonance study

ST-segment elevation myocardial infarction (STEMI) often results in microvascular injury, including intramyocardial haemorrhage (IMH), despite successful reperfusion. This study explored whether the stress hyperglycaemic ratio (SHR) is independently associated with IMH in STEMI p...

Lycium barbarum glycopeptide attenuates ischaemic stroke by inhibiting inflammation via SIRT3-mediated NLRP3 deacetylation

Background Inflammatory processes play a critical role in ischaemic stroke. Acetylation of NLRP3 is a key step in amplifying neuroinflammation. (LbGP), a bioactive glycoprotein derived from Lycium barbarum, has anti-inflammatory potential, but its mechanisms in post-stroke neuroi...