Levanger Hospital

Direct and indirect estimation of reference limits for hematologic parameters in adults included in the HUNT study

Reliable reference limits for hematological parameters are essential for clinical interpretation. In this study, we estimated reference limits for hemoglobin, erythrocytes and MCH using direct and indirect methods on data from the Trøndelag Health Study (HUNT). Results from 53,59...

Device measured physical activity among women with and without adverse pregnancy outcomes: Data from the HUNT study

Background Women with a history of adverse pregnancy outcomes (APOs), including gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), small for gestational age (SGA) offspring, preterm birth and placental abruption, are at increased risk of cardiovascula...

Targeting Reactive Species Stress and Nutrient Sensing to Enhance NK-Cell Function: Mechanistic Strategies for Overcoming Pancreatic Cancer Progression and Resistance Through Supplement Therapy

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited treatment success and strong resistance to therapy. Natural killer (NK) cells are important immune cells that can destroy cancer cells, and their function can be improved through certain micronutr...

Naïve adaptive immune receptor repertoires in celiac disease assessed by machine learning; impact of the HLA-DQ2.5 allotype on the TCR repertoire

Abstract The adaptive immune receptor repertoire (AIRR) - the collection of an individual’s B-cell and T-cell receptors (BCRs and TCRs, respectively) - encodes cumulative immune history and is shaped by both germline genetics and environmental exposures. Skewed repertoires have b...