Leipzig University of Applied Sciences

Effect of pipe-end geometry on powder charging and electrostatic discharge in a silo

Electrostatic charging of insulating powders during pneumatic conveying can cause hazardous discharges during storage-vessel loading. This study investigated the effect of pipe-end geometry on powder charging and electrostatic discharge behavior during silo loading using tongue-s...

Curriculum for Bioimaging Data Stewardship: A Systematic Review of Existing Training Resources

Abstract The increasing complexity and volume of biological imaging data require structured and sustainable research data management to ensure reproducibility, reusability, and compliance with FAIR (Findable, Accessible, Interoperable, and Reusable) principles. In this context, D...

Enhanced survival through repeated photodynamic therapy and almost complete tumor regression by prior radiation therapy in an orthotopic rat bladder cancer model

Abstract Introduction The development of new organ-preserving treatment alternatives is still an important issue in bladder cancer (BCa) research. A combination of minimally-invasive photodynamic therapy (PDT) with ionizing radiation (IR) could be beneficial for bladder tumor reg...

From Conflict to Coordination: Children as Strategic Problem Solvers in Social Dilemmas

Human cooperation requires resolving social dilemmas—situations in which individual interests conflict with what is best for the group. A growing body of work has begun to explore how children develop and implement solutions to these conflicts, shedding new light on the developme...

From Inhibitor to Reporter: Nirmatrelvir-Derived Fluorogenic Substrates for the SARS-CoV-2 Main Protease

The SARS-CoV-2 main protease (Mpro) is a key antiviral drug target due to its essential role in the pathogen's replication cycle. The development of potent next-generation Mpro inhibitors is of great importance to ensure the availability of safe and effective COVID-19 therapeutic...

Mechanochemical energy landscapes under force support catch–slip bonds in T-cell activation

Abstract Traditional theories explain T-cell activation using antigen concentration, binding affinity and dissociation rate, but they fail to account for its extraordinary sensitivity. Recent developments in structural biology, biophysics and modelling have motivated the view tha...

P1.005. Preliminary Pilot Study Cohort Results - Cost-Effective Surveillance Strategies and Prediction of Cancer Recurrence After Endoscopic Therapy for Barrett’s Esophagus (Endeavor)

Abstract Topic Esophageal Cancer: Barrett‘s Esophagus: High-Grade Dysplasia and Early Invasive Cancer Background In many European countries, esophageal adenocarcinoma (EAC) incidence is increasing [1]. Barrett’s esophagus(BE), strongly associated with EAC, can progress via dyspla...

Some degrees of difference: impact of in vitro cultivation temperature on mesenchymal stromal cells from species with different body core temperatures

Abstract Background Multipotent mesenchymal stromal cells (MSC) are promising candidates for regenerative therapies in human and animal patients. However, limiting comparability between studies in different species, subtle differences between their MSC occur. Contributing to this...

Quantifying authenticity in historic districts: an integrated framework of morphological indicators and social perception based on Scenes Theory

Tourism commercialization poses growing challenges to the preservation of authenticity in historic districts. Current conservation practices often focus on physical spaces, yet may overlook the integrity of “Scenes” as an integration of material and intangible elements, potential...

Generalizing reduced rank extrapolation to low-rank matrix sequences

Abstract Reduced rank extrapolation (RRE) is an acceleration method typically used to accelerate the iterative solution of nonlinear systems of equations using a fixed-point process. In this context, the iterates are vectors generated from a fixed-point mapping function. However,...

Holocene hydroclimatic variability and multi-frequency analyses at Lake Sidi Ali (Morocco)

Abstract. The North African desert margin is considered one of the most sensitive areas to future climate changes, yet the periodicities, coupling mechanisms and external forcing of Holocene environmental variability remain poorly understood. To investigate millennial- to centenn...

Systemic influences on orthodontic tooth movement: mechanisms and clinical implications

Orthodontic tooth movement (OTM) is a complex biological process involving bone remodeling, which can be significantly affected by systemic diseases and systemic factors. This review comprehensively examines how systemic conditions such as diabetes mellitus, thyroid dysfunction,...

Predict-then-optimise interchange control for rail logistics with combined passenger-freight chains

Interchange decisions at rail transfer stations directly affect end-to-end service reliability and cost-to-serve; yet, existing delay-management approaches either forecast delays without prescribing actions or optimise dispatch with coarse delay representations. We propose a pred...