Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)

Two cases of an imatinib-sensitive PRKG2::PDGFRA-positive chronic myeloid neoplasm with basophilia

The clinical and morphological phenotype of myeloid/lymphoid neoplasms with tyrosine kinase (TK) gene fusions (MLN-TK) is influenced by both the TK and the partner gene [ 1 ]. Here, we report on two patients with an initial diagnosis of a chronic myeloid neoplasm with prominent b...

Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging

Abstract Proteostasis is essential for maintaining neuronal function, and its dysregulation is a hallmark of aging and neurodegeneration. The ubiquitin-proteasome system (UPS) and macroautophagy are the two major proteolytic pathways responsible for protein degradation. However,...