Leibniz Institute for Prevention Research and Epidemiology - BIPS

Bridging policy and implementation science: operationalising political and structural determinants for health policy implementation evaluation

Abstract Background Despite their critical role in shaping public health policy implementation, key political and structural determinants within implementation frameworks are often poorly defined, underreported, or treated as background rather than as core implementation variable...

The HEADSpAcE Data Center: An international data and biospecimen resource for head and neck cancer translational research

Head and neck cancer (HNC) comprises a heterogeneous group of malignancies with substantial variation in incidence, risk factors, and outcomes across populations. Existing studies are often limited by regional scope or lack integration of epidemiological, clinical, and molecular...

Device-Measured Physical Activity, Sedentary Time, and Cardiometabolic Risk Markers in Youth

Importance The evidence for benefits of higher physical activity and lower sedentary time on the cardiometabolic risk profile in youth is based on cross-sectional and small prospective studies. Objective To determine the prospective associations between device-measured physical a...

xplainfi: Feature Importance and Statistical Inference for Machine Learning in R

We introduce xplainfi, an R package built on top of the mlr3 ecosystem for global, loss-based feature importance methods for machine learning models. Various feature importance methods exist in R, but significant gaps remain, particularly regarding conditional importance methods...

Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals

Abstract DNA double-strand breaks (DSBs) which arise in G1- or G0-phase normal human cells are repaired by non-homologous end-joining (NHEJ), a pathway which is important for cell survival but can cause mutations at the break sites. DSB repair by NHEJ is very efficient at high da...

Vaccinations during pregnancy in Germany between 2004 and 2022: a claims data analysis

Abstract Data on vaccinations during pregnancy are lacking in Germany. We aimed to assess the proportion of pregnancies with any vaccination over a 19-year period. Using health claims covering approximately 20% of the German population, we included pregnancies beginning between 2...