Lehigh Valley Hospital-Pocono

Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic cancer: the randomized phase 2 AMPLIFY-7P trial

Camupepimut (ELI-002 7P) drives mutated KRAS (mKRAS)-specific T cell responses that correlated with disease-free survival (DFS) and overall survival (OS) in patients with mKRAS pancreatic adenocarcinoma (PDAC) in the phase 1 AMPLIFY-201 trial. In the phase 2 AMPLIFY-7P trial, pat...

Machine Learning Prediction of Treatment Failure After Middle Meningeal Artery Embolization for Subdural Hematoma

BACKGROUND AND OBJECTIVES: Middle meningeal artery embolization (MMAE) is effective for chronic subdural hematoma (SDH), but failure rates vary and risk prediction tools are lacking. This study developed and validated a machine learning (ML) model to predict MMAE treatment failur...

Composite Cap Grafting for Fingertip Amputations in Pediatric Patients: Does Patient Age Matter?

Background: Fingertip avulsions are one of the most common pediatric hand injuries with composite “cap” grafting being a typical intervention. However, composite grafting can be unpredictable, and little is published on its expected clinical course. Therefore, we sought to determ...

Acute Alcohol-Associated Hepatitis: The Role of Liver Transplantation

Severe alcohol-associated hepatitis (AH) remains one of the most challenging syndromes in hepatology and critical care, with high short-term mortality despite advances in supportive management. Although corticosteroids remain the only guideline-endorsed pharmacologic therapy show...

Donor Site Scarring and Dyspigmentation Following Split-Thickness Skin Graft Procedure: A Large-Sample, Single-Site Retrospective Study

Abstract Split-thickness skin grafts are essential for managing burns and non-healing wounds, but donor site complications such as dyspigmentation and hypertrophic features can impair long-term donor site appearance. Evidence on risk factors for donor site morbidity in large, div...