Lehigh Valley Health Network

Machine Learning Prediction of Treatment Failure After Middle Meningeal Artery Embolization for Subdural Hematoma

BACKGROUND AND OBJECTIVES: Middle meningeal artery embolization (MMAE) is effective for chronic subdural hematoma (SDH), but failure rates vary and risk prediction tools are lacking. This study developed and validated a machine learning (ML) model to predict MMAE treatment failur...

Acute Alcohol-Associated Hepatitis: The Role of Liver Transplantation

Severe alcohol-associated hepatitis (AH) remains one of the most challenging syndromes in hepatology and critical care, with high short-term mortality despite advances in supportive management. Although corticosteroids remain the only guideline-endorsed pharmacologic therapy show...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Donor Site Scarring and Dyspigmentation Following Split-Thickness Skin Graft Procedure: A Large-Sample, Single-Site Retrospective Study

Abstract Split-thickness skin grafts are essential for managing burns and non-healing wounds, but donor site complications such as dyspigmentation and hypertrophic features can impair long-term donor site appearance. Evidence on risk factors for donor site morbidity in large, div...