Leeds Teaching Hospitals NHS Trust

Safety of routine antimicrobial prophylaxis for surgery (SAPPHIRE): a prospective multi-centre cohort study

Introduction: Prophylactic antimicrobial drugs are routinely administered for most surgical procedures worldwide. However, the benefit may be modest and supported by low-certainty evidence, while little is known about safety in contemporary practice.<br><br>Methods: O...

Do Patients Receiving GLP-1 Receptor Agonists for Weight Loss Require Structured Dietetic Care? Lessons from Metabolic and Bariatric Surgery (MBS) Pathways

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual incretin therapies have significantly advanced obesity management by facilitating clinically significant weight loss and enhancing cardiometabolic outcomes. Nevertheless, their growing application calls fo...

The Concept of Biological Resectability in Pancreatic Ductal Adenocarcinoma — An Updated Narrative Review

Resectability in pancreatic ductal adenocarcinoma (PDAC) has traditionally been defined according to tumor–vessel relationship on cross-sectional imaging. However, anatomical criteria alone fail to identify occult systemic disease and do not reliably predict early postoperative r...

Pulmonary metastasectomy in solid tumors: a single-center experience at a tertiary referral center in the Middle East

Despite advances in systemic therapy, pulmonary metastasectomy remains a key option for selected patients with metastatic solid tumors, offering long-term survival. Prognosis is influenced by many factors including disease-free interval and metastatic burden. This study evaluates...