Institution
Leeds Teaching Hospitals NHS Trust
Recent research
- Health & MedicineOpen access
OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...
- Health & MedicineOpen access
Accepted: 2026) UK consensus recommendations for onward testing for Lynch Syndrome in patients
- Health & MedicineOpen access
BACKGROUND: Maternal mortality remains a major challenge in Uganda, where the maternal mortality ratio is 189 per 100,000 births - fifty time higher than in the UK. The Royal College of Obstetricians and Gynaecologists' Excellence in Obstetric Skills (EOS) and Resilience in Obste...
- Society & EconomicsOpen access
Potential treatment-cost savings from stage-shift in head and neck cancer in England
BACKGROUND: Head and neck cancer (HNC) poses a significant and growing economic burden on the NHS. Treatment costs are higher for late-stage disease, yet most patients in England present at advanced stages. Population-level screening may shift stage distribution at diagnosis, but...
- Health & MedicineOpen access
Association Between Genetic Ancestry and Multiple Sclerosis Severity
OBJECTIVE: The objective of this study was to determine whether genetic ancestry is associated with differences in the clinical course of multiple sclerosis (MS). METHODS: Participants with MS living in the United Kingdom >18 years old were recruited from 2021 to 2025 and genotyp...
- Health & MedicineOpen access
Abstract Background Investment in vitreoretinal (VR) surgery in sub-Saharan Africa (SSA) is constrained by perceptions of high cost and limited benefit, yet no economic evaluations exist to inform policy decisions. This study assessed the feasibility of conducting economic evalua...
- Health & MedicineOpen access
Adolescents and young adults (AYAs, aged 15-39 years at cancer diagnosis) are recognized as a distinct patient group with specific clinical and psychosocial needs requiring tailored care. This article presents the Network of Expertise (NoE) on AYAs with cancer developed through t...
- Health & Medicine
How to manage: acute-on-chronic liver failure
Acute on chronic liver failure has emerged as a distinct clinical entity over the past few decades. While mortality remains highest for patients who develop liver and multiple non-liver organ failures, earlier recognition of the syndrome, including identification and management o...
- Health & MedicineOpen access
Abstract Purpose To evaluate whether baseline well-delineated hyperreflective material (wdHRM) is associated with short-term visual outcome in treatment-naïve neovascular age-related macular degeneration (nAMD), whether this association differs by macular neovascularisation (MNV)...
- Health & MedicineOpen access
Fatigue in bronchiectasis: An under-recognised treatable trait
Fatigue is frequently reported by people living with bronchiectasis, yet remains among the least systematically studied of its symptoms.1–3 In routine practice it is often mentioned briefly and the...
- Health & MedicineOpen access
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- Health & MedicineOpen access
The incidence of cutaneous melanoma (CM) is increasing among elderly patients, who often present with advanced disease, including cutaneous metastases. Electrochemotherapy (ECT) is a local ablative treatment that enhances chemotherapy uptake via electric pulses. Management in pat...
- Health & MedicineOpen access
Abstract Background Dyspnea is a prominent symptom in patients with warm autoimmune hemolytic anemia (wAIHA), yet its lived experience remain under-researched. Although clinically relevant, dyspnea is not routinely assessed in wAIHA trials, and no validated patient-reported outco...
- Health & Medicine
Abstract Introduction Despite advances in surgery and radiotherapy, glioblastoma patients often experience progression within a year, adjacent to the resection cavity. Conventional imaging techniques are not sensitive enough to detect invasive tumour, leaving occult tumour undete...
- Health & Medicine
ABSTRACT Background Free flap harvesting from paralyzed limbs represents a potentially valuable approach in reconstructive microsurgery, yet its safety and efficacy remain incompletely characterized. This systematic review evaluates the feasibility, safety, and outcomes of free f...
- Health & Medicine
Summary Primary mediastinal B‐cell lymphoma (PMBCL) is a distinct clinicopathological entity within the spectrum of aggressive B‐cell lymphomas, characterised by unique clinical, immunophenotypic and molecular features. Since publication of the 2019 British Society for Haematolog...
- Health & MedicineOpen access
Introduction: Prophylactic antimicrobial drugs are routinely administered for most surgical procedures worldwide. However, the benefit may be modest and supported by low-certainty evidence, while little is known about safety in contemporary practice.<br><br>Methods: O...
- Health & MedicineOpen access
Resectability in pancreatic ductal adenocarcinoma (PDAC) has traditionally been defined according to tumor–vessel relationship on cross-sectional imaging. However, anatomical criteria alone fail to identify occult systemic disease and do not reliably predict early postoperative r...
- Health & MedicineOpen access
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual incretin therapies have significantly advanced obesity management by facilitating clinically significant weight loss and enhancing cardiometabolic outcomes. Nevertheless, their growing application calls fo...
- Health & MedicineOpen access
Despite advances in systemic therapy, pulmonary metastasectomy remains a key option for selected patients with metastatic solid tumors, offering long-term survival. Prognosis is influenced by many factors including disease-free interval and metastatic burden. This study evaluates...