Latvijas Organiskās Sintēzes Institūts

Lysine-Based Amphiphiles with Pyrrole, Furan and Thiophene Linkers

The development of efficient cationic amphiphiles remains an important area in the design of nonviral systems for nucleic acid delivery. In this study, we report the synthesis of three lysine-containing lipid-like amphiphiles incorporating pyrrole, furan, and thiophene as five-me...

Adenosine5′-Carboxamide-Based Inhibitors ofMETTL1

Abstract METTL1 is the human RNA methyltransferase that catalyzes the methylation of N7-guanosine in RNA. Overexpression of METTL1 has been linked to cancer, and increasing evidence supports the therapeutic potential of METTL1 inhibition in oncology. In this study, we have optimi...