Latvijas Organiskās Sintēzes Institūts

Adenosine5′-Carboxamide-Based Inhibitors ofMETTL1

Abstract METTL1 is the human RNA methyltransferase that catalyzes the methylation of N7-guanosine in RNA. Overexpression of METTL1 has been linked to cancer, and increasing evidence supports the therapeutic potential of METTL1 inhibition in oncology. In this study, we have optimi...