Lanzhou University Second Hospital

Attapulgite Nanocomposites for Cartilage and Osteochondral Repair: Material–Tissue Matching, Evidence-Graded Mechanisms and Translation

Attapulgite (ATP; palygorskite) is a fibrous magnesium aluminum silicate that can reinforce hydrated polymer networks, provide a surface for molecular interactions, and participate in formulation-dependent ion or drug delivery. Although ATP has been studied most extensively in bo...

Integrated interpretability machine learning and clinlabomics analysis for the risk prediction of hepatocellular carcinoma

This study aimed to develop a hepatocellular carcinoma (HCC) risk prediction model based on clinlabomics and develop an online prediction tool to provide a novel approach for early HCC diagnosis. We retrospectively collected clinical and laboratory data from 1,017 patients (576 H...

Botulinum toxin type A attenuates trigeminal neuralgia-like pain by suppressing CGRP release and modulating NaV1.7-associated signaling

Trigeminal neuralgia (TN) is a disabling facial pain disorder, and current treatments remain insufficient for a substantial proportion of patients. Botulinum toxin type A (BoNT/A) has shown therapeutic benefit in TN, but its peripheral analgesic mechanisms remain incompletely und...

Lateral Transperitoneal Versus Posterior Retroperitoneoscopic Adrenalectomy for Adrenal Tumors: A Randomized Controlled Trial

Introduction: A randomized controlled trial was conducted to compare the clinical efficacy of lateral transperitoneal adrenalectomy (LTA) versus posterior retroperitoneoscopic adrenalectomy (PRA) and to explore suitable surgical approaches for different patients. Methods: This pr...

Gut Lysophosphatidylcholine Aggravates Donation After Circulatory Death Liver Injury via Lysosomal Dysregulation During Normothermic Regional Perfusion

Background. Normothermic regional perfusion (NRP) is increasingly used in donation after circulatory death liver transplantation, yet the impact of the accompanying intestinal ischemia/reperfusion injury and gut microbiota dysbiosis on liver grafts remains unclear. Methods. A rat...

Gliomas grading prediction using multicenter 3T Magnetic Resonance Spectroscopy

Abstract Background Magnetic Resonance Spectroscopy (MRS) is a non-invasive imaging technique that detects various metabolites in brain tissues, making it essential for the grading of brain gliomas. MRS measures key metabolites such as N-acetyl-aspartate (NAA), choline (Cho), and...