Lanzhou City University

CD147+ Cancer‐Associated Fibroblasts Promote PD‐L1 Expression in Hepatocellular Carcinoma via TIMP2/MMP2/IL‐6 Signaling

BACKGROUND: Targeting CD147 on hepatocellular carcinoma (HCC) cells has demonstrated therapeutic efficacy. Cancer-associated fibroblasts (CAFs) have been identified as critical components of the tumor microenvironment. The role of CD147 in CAFs is still unclear, and this study ai...

Predictive modeling and engineering validation of ladle draining in bottom pouring

In bottom pouring, ladle draining directly affects mold filling stability, solidification behavior, and ingot quality. To describe the draining process under the combined effects of a continuously decreasing liquid level and changes in slide-gate opening, a predictive mathematica...

Chemodivergent Synthesis of Indole Derivatives: [2 + 3]-Annulation of Oxindole-Derived MBH Carbonates with α-Enolic Dithioesters and Subsequent Branching Transformations

Abstract A chemodivergent synthetic strategy for constructing a series of structurally diverse indole derivatives has been developed, utilizing oxindole-derived Morita-Baylis-Hillman (MBH) carbonates and α-enolic dithioesters as key building blocks. By leveraging the unique react...

Integrated multi‐omics analysis of post‐translational modifications in head and neck squamous cell carcinoma: elucidating x‐ray and carbon ion irradiation effects

Abstract Background and purpose Head and neck squamous cell carcinoma (HNSCC) exhibits heterogeneous responses to radiotherapy; however, the underlying multi‐omics regulatory networks remain poorly characterized. This study elucidated the distinct post‐translational modification...

Multi-view stereo and planar Gaussian splatting for generalizable surface reconstruction

Image-based three-dimensional (3D) reconstruction and novel view synthesis (NVS) play a critical role in applications such as virtual/augmented reality, 3D content generation, and autonomous driving. Recent studies have explored the integration of multi-view stereo (MVS) priors w...

Exogenous SA- and IAA-Mediated Regulation of Silique Growth and Development in Isatis indigotica

Isatis indigotica Fort.—a well-known medicinal cruciferous species—is the source plant of Isatidis Radix and Folium Isatidis, and is widely cultivated for medicinal raw material. The silique serves as the propagative organ for seed production of I. indigotica, and its development...

Unveiling the role of AI tools in language learning: a bibliometric study

Artificial intelligence (AI) tools increasingly mediate language teaching, learning, feedback, and interaction. This study uses bibliometric analysis to map the development, intellectual structure, and emerging themes of research on AI tools in language learning. The dataset comp...

Atomic Engineering of Single Crystals: Designing High‐Efficiency Bifunctional Co/Fe Single‐Atom and Alloy Catalysts for Zinc‐Air and Zinc‐Ion Batteries

ABSTRACT Single‐crystalline metal oxides offer well‐defined coordination environments to suppress metal migration, yet their application as precursors for bifunctional oxygen electrocatalysis remains limited. In this study, single‐crystal x‐ray diffraction and Fourier‐transform i...

Integrating machine learning and data-driven modelling: predicting dengue outbreaks and revealing spatially heterogeneous climatic drivers in Brazil

Dengue fever poses a major global health threat, with Brazil experiencing severe recurrent outbreaks driven by climatic, socio-economic and mobility factors. Accurate prediction remains challenging owing to dynamically shifting transmission patterns under intervention. This study...

Result-Oriented Generation Meets Process-Oriented Creation: Understanding the Tension Between Generative AI and Craft Practice

Generative artificial intelligence (GenAI) is reshaping creative work, yet research focuses mainly on digital creation, with limited attention to embodied practices grounded in material interaction and physical making. Taking craft as an entry point, we examine GenAI in craft thr...

Effects of Guozhuang dance participation on alexithymia in healthy adults: The chain mediating roles of empathy and social connectedness

This study examined the association between participation in Guozhuang dance and alexithymia among healthy adults, with cognitive empathy and social connectedness as potential mediators. A total of 560 healthy adults completed the Physical Activity Rating Scale-3, Basic Empathy S...

Rapid Colorimetric Detection of Free and Complexed Cr3+ Based on a Tetrabutylphosphonium Bromide/Gold Nanoparticle Anti-Aggregation System

Existing colorimetric sensing strategies based on gold nanoparticles (AuNPs) are largely limited to the detection of free metal ions, leaving metal-organic complexes widely present in real water bodies undetectable. Herein, we develop a simple colorimetric method based on the ant...

Reconfiguration of rural social-spatial network by mobile social platform and its impact on apple farmer livelihoods: a case study of Li County, China

Abstract Digital transformation is profoundly reshaping rural socio-economic landscapes and livelihood trajectories worldwide. However, the spatially differentiated mechanisms through which specific mobile social platforms reconfigure farmers’ social-spatial networks and the cons...

Botulinum toxin type A attenuates trigeminal neuralgia-like pain by suppressing CGRP release and modulating NaV1.7-associated signaling

Trigeminal neuralgia (TN) is a disabling facial pain disorder, and current treatments remain insufficient for a substantial proportion of patients. Botulinum toxin type A (BoNT/A) has shown therapeutic benefit in TN, but its peripheral analgesic mechanisms remain incompletely und...

Evaluation of the Impact of Aged Biomass Burning Emissions on the Global Ozone From the Surface to the Lower Stratosphere

Abstract Biomass burning (BB) is a major global sources of ozone (O 3 ) precursors, including nitrogen oxides (NO x ), carbon monoxide (CO), and volatile organic compounds (VOCs). Here, we combine Community Earth System Model 1 with airborne measurements from the NASA Atmospheric...