Lankenau Institute for Medical Research

Liquid Biopsy-Guided Surgical Decision-Making in Oligometastatic Non-Small Cell Lung Cancer: Toward Dynamic Risk Stratification in the Multidisciplinary Era

Oligometastatic non-small cell lung cancer (NSCLC) is defined anatomically by a threshold of five or fewer metastatic lesions across three or fewer organs. That definition is a proxy for a biological question it cannot answer: whether the metastatic process has been arrested at a...

Molecular Dynamics-Guided Triage of Approved Drugs Against Escherichia coli Resistance Targets Nominates Capmatinib, Metergoline and Nilotinib as Candidates for Experimental Testing

Virtual screening ranks compounds by scoring functions that correlate with molecular size, and hit lists are rarely benchmarked against compounds of established activity. We screened 2070 approved drugs against four Escherichia coli targets selected by pocket-druggability triage...

What the Etude Taught Me: On Music, Surgery, and a Pedagogy Worth Borrowing

Surgical dexterity is a motor skill, and motor skills are teachable. Surgical education has built an increasingly sophisticated apparatus for teaching them, from mastery-based knot-tying curricula and home skills laboratories to operative video atlases, coaching programs and sens...

Evaluation of an AI-based digital pathology tool for breast cancer recurrence risk

Hormone receptor-positive (HR+) breast cancer is the most common type among women in the United States. Multigene assays such as Oncotype DX (ODX) assess recurrence risk and chemotherapy benefit but are costly and time-consuming. This exploratory study evaluates the AI-powered Pr...