Lancashire Teaching Hospitals NHS Foundation Trust

Knotless Suture Repair For Chronic Lateral Ankle Instability: A Systematic Review and Single-Arm Meta-Analysis

Introduction There is a need to assess the use of knotless sutures in cohorts with chronic ankle instability (CAI). Methods A literature search of Embase, Ovid MEDLINE, Cochrane Library and Scopus was conducted from each database’s inception to August 15, 2025. Eligible studies r...

Essex-Lopresti Injuries: A Systematic Review

Abstract Essex-Lopresti injuries (ELIs) are rare, and complex forearm injuries involving radial head fracture, interosseous membrane (IOM) rupture, and distal radioulnar joint (DRUJ) instability. We performed a systematic review to define diagnostic criteria, explore treatment st...

Predicting the Unpredictable: Development and External Validation of the GO SOAR Surgical Risk Calculator for Data-Driven Predictions of Surgical Complications in Gynaecological Oncology Surgery

Background/Objectives: Universal surgical risk calculators are not validated for use and poorly predict postoperative morbidity and mortality for women undergoing gynaecological oncology surgery. This adversely affects communication of risk resulting in poorly informed decisions...

The Transition of Youth With Diabetes From Pediatric to Adult Diabetes Care Services: A Consensus Report of the Joint Working Group of the International Society for Pediatric and Adolescent Diabetes (ISPAD), the European Association for the Study of Diabetes (EASD), and the American Diabetes Association (ADA)

Young adulthood is a period of significant and unique physiological, psychological, sexual, and social upheaval. Related challenges can have an impact on effective diabetes self-management, with high rates of unplanned health care use recorded for many, and consequent increases i...

Long-Term Clinical and Economic Impact of Automated Insulin Delivery Systems Use in Pediatric and Adolescents Type 1 Diabetes: Results Across Australia, Canada, the UK, and the USA

BACKGROUND AND AIMS: Automated Insulin Delivery (AID) systems are the recommended standard of care for Type 1 Diabetes (T1D) management in children and adolescents, according to latest international guidelines. This study aims to assess the cost-effectiveness of AID systems for p...

Efficacy and Safety of Sacituzumab Govitecan for Breast Cancer

Objectives: Sacituzumab govitecan (SG), a Trop-2-directed antibody-drug conjugate, has demonstrated clinical activity in HER2-negative breast cancer. Our meta-analysis aimed to evaluate the efficacy and safety of SG compared with standard chemotherapy in patients with breast canc...

Does pre-operative neutrophil–lymphocyte ratio predict patient-reported pain and functional outcomes at 12 months after anterior cervical discectomy and fusion?

INTRODUCTION: Preoperative neutrophil-lymphocyte ratio (NLR) has been found in various fields to be a predictor of post-operative pain and functional outcomes. To date no studies have looked at NLR in relation to patient outcomes after anterior cervical discectomy and fusion (ACD...

Ventricular Tachycardia Ablation in Nonischemic Cardiomyopathy: Is Pulsed Field Ablation the Next Paradigm Shift?

Ventricular tachycardia ablation in nonischemic cardiomyopathy remains limited by high recurrence rates despite advances in catheter-based techniques. In nonischemic cardiomyopathy, the arrhythmogenic substrate is often heterogeneous and may involve intramural or epicardial myoca...