Lahey Medical Center

Recurrence Rates and Outcomes After First Detected Atrial Fibrillation Episode in a Contemporary Hypertrophic Cardiomyopathy Center

Background: Atrial fibrillation (AF) is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), occurring in 20–25% of patients and associated with increased morbidity, stroke risk, and symptom burden. Despite this substantial clinical impact, the understanding...

Safety of Subcutaneous Heparin in Patients Requiring External Ventricular Drains.

BACKGROUND AND OBJECTIVES: External ventricular drain (EVD) placement and removal to manage intracranial pressure carry an inherent risk of hemorrhage, which complicates chemoprophylactic management of venous thromboembolism (VTE). VTE chemoprophylaxis with subcutaneous (SQ) hepa...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment. Aficamten is a cardiac myosin inhibitor targeting excess contractility and diastolic impairment, the predominant mechanism responsible for adverse ou...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Angioarchitectural characterization of transdural supply in brain arteriovenous malformations: a multicenter retrospective study

Transdural supply (TDS) is a recognized angioarchitectural feature of brain arteriovenous malformations (bAVMs). We aimed to systematically characterize the angioarchitecture of TDS in bAVMs, focusing on whether transdural feeders terminated within the nidus or connected directly...

Quantum-inspired scenario-adaptive differential privacy with hybrid attention–residual deep learning for utility-aware urban location analytics

Abstract Location-based services (LBS) increasingly rely on trajectory data, creating a persistent challenge in balancing user privacy and data utility. Conventional differential privacy (DP) mechanisms often employ fixed noise distributions and global privacy budgets, limiting t...

“I Just Need Guidance Through This Maze I’m Going Through”: Addressing Unmet Basic and Mental Health Needs to Facilitate Engagement in HIV Prevention Services in the Context of Stimulant Use

There is a global syndemic of HIV, mental health challenges, substance use, and structural barriers. Critical to local HIV prevention efforts is understanding this syndemic in the context of rising stimulant use to inform intervention development. Adhering to the EPIS model, we c...