Laboratoire d’immunologie intégrative du cancer

Investigating the clinical utility of plasma succinate with insights from a Sdhb deficient murine model

Abstract The succinate dehydrogenase (SDH) enzyme composed of four subunits (A-D) has a key role in the Krebs cycle and oxidative phosphorylation. Germline pathogenic variants (GPV) in the genes encoding the four subunits of the succinate dehydrogenase (SDH) enzyme (SDHA/SDHB/SDH...

Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling, often irreversible toxicity that affects millions of patients, limits life-saving cancer therapy, and lacks proven treatment. In this work, we show that as little as two doses of psilocybin before chemotherapy dura...

Lipids in endothelial-to-mesenchymal transition

Purpose of review Endothelial-to-mesenchymal transition (EndMT) has been implicated in the development of cardiovascular disease, including atherosclerosis. EndMT is a complex continuum with multiple involved pathways, each with different pathophysiologic implications depending o...