Laboratoire de Chimie

Deciphering Aggregation-Induced Tunable Circular Dichroism of AuBP@Ag and AuBP@Au Chiral Core–Shell Plasmonic Nanoparticles

Abstract Plasmonic nanoparticles exhibiting strong and tunable chiroptical signals have been drawing much interest recently due to their potential vast applications. A few years ago, it was shown that seed-mediated metal growth can be harnessed to make single nanoparticles intrin...

Pure Shift 2D NMR with Water Suppression for Structural and Dynamic Analysis of Flexible Molecules

Abstract Achieving high-resolution proton NMR spectra in aqueous media remains a major challenge for structurally complex and conformationally flexible molecules, where homonuclear scalar couplings and limited chemical-shift dispersion lead to severe spectral congestion. Here, we...

Weak Anion Hydration Drives LCST Behavior in Ionic Liquid–Water Mixtures: Insights from Calorimetry and Neutron Diffraction

Abstract Isothermal titration calorimetry (ITC) combined with neutron diffraction and isotopic substitution (NDIS) has been used to elucidate the molecular origins of lower critical solution temperature (LCST) behavior in the tetrabutylphosphonium 5-phenyltetrazolate/water ([P444...

Molecular basis of nick ligation in the nucleosome by DNA Ligase IIIα

Eukaryotic genomic DNA is packaged into chromatin through a fundamental repeating unit known as the nucleosome core particle. Within this chromatin context, genomic DNA is constantly exposed to endogenous and exogenous stress that result in the formation of DNA damage, which must...