La Jolla Institute for Immunology

COMBO ‐ RATE : An Experimentally Validated Bioinformatic Tool to Identify Promiscuous HLA Restrictions

ABSTRACT Defining HLA restriction of T cell epitopes is essential for understanding immune responses in infectious disease, autoimmunity and vaccine design. Current bioinformatic programmes, including the IEDB RATE tool, enable inference of single‐HLA restrictions from immune res...

Dengue virus controlled human challenge reveals that preexisting immunity shapes viral replication and broadly protective responses

Dengue is the canonical viral disease for which immune history is a determinant of protective versus pathogenic responses and immunogenicity. Yet, because of limitations in animal models and clinical presentation after peak viremia, how preinfection and early immune responses aff...

Herpesviruses show consistency in their nuclear egress-associated induction of lamina-depleted areas as measured in an autofluorescent reporter cell model

Abstract Human herpesvirus infections span a wide variety of pathogenic outcomes, with individual representatives comprising a huge clinical relevance on human health. Translational research efforts are directed towards the improvement of broadly applicable preventive measures an...

SUMO2 deletion changes chromatin accessibility and enhances cytotoxic T cell activation and tumor infiltration

Cytotoxic T cells [cytotoxic lymphocytes (CTLs)] are crucial for adaptive immunity leading to prolonged survival and potential cures for cancer. Recent clinical data have shown that pharmacological inhibition modifies the tumor microenvironment (TME) and activates CTLs, although...

Murmurations, Mestre–Nagao sums, and convolutional neural networks for elliptic curves

Abstract We apply one-dimensional convolutional neural networks to the Frobenius traces of elliptic curves over $$\mathbb {Q}$$ Q and evaluate and interpret their predictive capacity. In keeping with similar experiments by Kazalicki–Vlah, Bujanović–Kazalicki–Novak, and Pozdnyakov...

Comparison of physician‐authored and artificial intelligence‐generated after‐visit summaries: A blinded comparative study

BACKGROUND: After-visit summaries (AVSs) are essential for a safe hospital discharge, yet are often written above literacy levels, omit key information, and are produced under substantial clinical time pressure. Large language models (LLMs) offer a potential solution, while perfo...

Activation of IL-17+ ILC subsets in IL-18R-deficient mice during fungal allergen exposure

Abstract Group 2 innate lymphoid cells (ILC2s) are critical players during type 2 inflammation present in most forms of asthma. ILC2s are tissue-resident cells that produce cytokines IL-5 and IL-13 critical to eosinophilic airway inflammation, mucus production, remodeling, and hy...