L V Prasad Eye Institute

Medical Literature-Specific Artificial Intelligence: Analyzing the performance of OpenEvidence, Heidi Evidence, Consensus, and PubMed.ai in the context of Lacrimal Drainage Disorders

PURPOSE: This study aimed to report the performance of medical literature-specific artificial intelligence (MLS-AI) deep learning tools in the context of lacrimal drainage disorders. METHODS: Prompt engineering was performed using 22 previously validated questions and statements...

Regeneration and Cancer—The Two Sides of a “Stem Cell” Coin: The 2025 Mildred Weisenfeld Award Lecture

Stem cells endowed with properties of self-renewal and differentiation have opened new avenues for restoration and regeneration of damaged tissues. The same adult stem cells, when they undergo irreversible mutations, transform into cancer cells and generate a tumor. In this lectu...

A Major Review of Fungal Lacrimal Drainage Infections

Purpose: Lacrimal system infections, such as canaliculitis and dacryocystitis, are usually of bacterial etiology. We present a review of fungal lacrimal drainage infections. Methods: A literature review was conducted using Medline and Embase databases following PRISMA guidelines....

Lacrimal Gland Choristoma and Associated Ocular Anomalies

Lacrimal gland (LG) choristomas are ectopically located lacrimal gland tissue that present as mass lesions, and their diagnosis is confirmed by histopathology. The current study reviews cases of lacrimal gland choristoma published between 2016 and 2025 and reports a rare case of...

A novel ZEB1 splice-site variant causing early-onset type 3 posterior polymorphous corneal dystrophy and suspected corneal ectasia

Posterior polymorphous corneal dystrophy type 3 (PPCD3) is an autosomal dominant endothelial dystrophy caused by variations in the ZEB1 gene. We report a pediatric case presenting with progressive visual impairment associated with simultaneous features of corneal ectasia and endo...

Repositioning of Vertical Implantable Phakic Contact Lens

ABSTRACT Implantable phakic contact lens (IPCL) V2.0 has a special patterned hole on the leading left corner to ensure correct orientation and positioning. Incorrect orientation is an absolute indication for repositioning. We emphasize that incorrect orientation of a toric IPCL c...

Epigenetic Factor Dysregulation and Distinct Expression Signatures in Retinoblastoma: A Transcriptomic Analysis

Purpose: Transcriptional heterogeneity observed in retinoblastoma (RB) is unexplained by the limited genetic alterations identified. Epifactors, which can modulate transcriptional activity and oncogenic pathways, may contribute to this heterogeneity. However, knowledge regarding...

Inherited Retinal Dystrophy in an 11-month-old Infant with Yunis-Varon Syndrome and Homozygous FIG4 Mutation

Purpose: Inherited retinal dystrophies (IRDs) may present as isolated entities or as multisystem syndromes. Yunis-Varon syndrome (YVS), seen with homozygous FIG4 mutations, is a rare autosomal recessive disorder. Herein, we report a case of YVS associated with early-onset rod-con...

Effects of Morning and Evening Narrowband Blue Light and Myopic Defocus on Axial Length in Humans

Purpose To investigate the effects of morning and evening narrowband blue light exposure on axial length, and to examine the short-term effect of morning blue light combined with myopic defocus on axial length.Methods For objective 1, 18 individuals underwent 60 minutes of narrow...