Kyung Hee University Medical Center

A quality appraisal of clinical practice guidelines for herpes zoster and postherpetic neuralgia using the AGREE II instrument

Background: This study systematically assesses the methodological quality of both Western and traditional medicine clinical practice guidelines (CPGs) for herpes zoster (HZ) and postherpetic neuralgia (PHN) using the Appraisal of Guidelines Research and Evaluation (AGREE II) inst...

Health Policy for Obesity and Metabolic Syndrome in Asian Health Systems: Three Design Principles, Three Binding Constraints, and the Governance That Decides between Them

Background: Obesity drives metabolic syndrome and cardiometabolic disease in Asia, where complications develop at lower levels of adiposity than in Western populations. We reviewed Asian obesity policies to identify design features that support their durability and how access to...

Intrinsic Capacity in a Nationally Representative US Population

Abstract Background Intrinsic capacity (IC) is defined by the World Health Organization as the sum of an individual’s physical and mental abilities that support health and well-being. While well validated internationally, it has not been operationalized and validated in a nationa...

Maternal Influenza Infection During Pregnancy and Neuropsychiatric Disorders in Offspring

Importance Evidence on maternal influenza infection during pregnancy and offspring neuropsychiatric risk remains inconsistent and limited by methodologic concerns. Objective To evaluate the association of maternal influenza infection during pregnancy and offspring neuropsychiatri...

Exposure to residential greenness and subsequent risk of common mental disorders among individuals with COVID-19 in South Korea: A nationwide cohort study

Background Residential greenness is considered protective for mental health, but its impact on clinically diagnosed psychiatric disorders following COVID-19 remains unclear. This study investigated the association between residential greenness and risk of common mental disorders...

Hypoxia–ROS–HSP Triad Axis in Cancer: Mechanisms, Crosstalk, and Therapeutic Implications

Cancer remains one of the leading causes of mortality worldwide, accounting for approximately 20% of all deaths and posing a major threat to global health. Mechanistically, tumorigenesis is driven by complex molecular and cellular mechanisms that enable malignant cells to evade c...

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

Sociodemographic and Anthropometric Determinants of Body Dissatisfaction in a Sample of Spanish Adolescents: The EHDLA Study

Body dissatisfaction is prevalent among adolescents and linked to adverse outcomes. This study examined sociodemographic and anthropometric factors associated with body dissatisfaction in Spanish adolescents. Cross-sectional data from the Eating Healthy and Daily Life Activities...

Distinct clinical patterns of preterm infants vulnerable to intestinal injury identified by unsupervised clustering

BACKGROUND: Current necrotizing enterocolitis (NEC) diagnostic criteria fail to capture the full spectrum of intestinal injury. We aimed to identify diagnosis-independent clinical patterns of intestinal injury among vulnerable very low birth weight (VLBW) infants using unsupervis...

Pattern-related profiles of acupuncture points for pain management

In Traditional East Asian Medicine, acupoints are selected based on clinical symptoms and pattern identification. Since treatment plans target specific diseases and patterns, acupoints may be selected based on clinical indications or pattern-related considerations. This study aim...

Does a Multi-Location CT Scan Provide a Survival Benefit as Surveillance after Curative-Intent Surgery in Early-Stage Non-Small Cell Lung Cancer?

Purpose: The NCCN guidelines recommend a chest computed tomography (CT) scan every 6 months for 2-3 years for patients with early-stage non-small cell lung cancer (NSCLC). This study aimed to evaluate whether multi-location CT scans offer a survival benefit. Materials and Methods...

Molecular Pathogenesis, Global Epidemiological Trends, and Treatment Strategies for Pteropine Orthoreoviruses: A Narrative Review

Pteropine orthoreoviruses are emerging bat-borne zoonotic viruses of the genus Orthoreovirus (family Reoviridae), increasingly recognized as causes of acute respiratory disease in humans. Originally grouped with the largely non-pathogenic mammalian orthoreoviruses, they have chal...

Defining the problem of pandemic resource allocation: perspectives from healthcare providers and civil society advocates in South Korea

Abstract Background The COVID-19 pandemic raised ethical questions about how scarce medical resources should be defined and allocated. Existing debates have largely focused on triage criteria and distributive principles, with less attention to how different social and institution...

Profiling of pyrimidine and arginine metabolism in NSCLC identified Malate-Aspartate Shuttle as the backbone network

Abstract Metabolic shifts are crucial for cellular proliferation, however, the roles of various metabolic pathways and their interconnections in NSCLC remain unclear. This lack of understanding in metabolic shifts precludes better cancer management as well as effective therapeuti...

Perceived training needs and barriers among Korean residents: a cross-sectional survey for competency-based education

PURPOSE: Current South Korean resident education relies heavily on apprenticeship models rather than the systematic curricula needed for multifaceted competency development. Therefore, a rigorous needs assessment is required for effective program design, particularly to target ye...

Structural barriers to knowledge co-production in the context of public health crisis

Abstract Knowledge translation (KT) is widely recognized as essential for evidence-informed policymaking, yet the research-policy gap persists. Co-production, namely collaborative knowledge production among researchers, policymakers, and practitioners, has emerged as a promising...

Quality of life assessment in individuals with schizophrenia: a COSMIN-based systematic review of S-QoL41 and S-QoL18 incorporating neurobiological support

Background Quality of life is a key outcome in schizophrenia, requiring valid patient-reported outcome measures. We evaluated Schizophrenia Quality of Life (S-QoL) instruments. Methods We searched PubMed, PsycINFO, and Web of Science from inception to Dec 10, 2025. Measurement pr...

The burden of low back pain in the United States, 1990 to 2021

Low back pain (LBP) is a major global health concern and remains a leading contributor to healthcare expenditure in the United States (US). Few recent studies have systematically analyzed the temporal, geographic, and demographic patterns of LBP burden and its associated risk fac...

Gut microbiota contributes to the therapeutic effect of acupuncture in atopic dermatitis

ABSTRACT The gut microbiome is increasingly recognized as a central regulator of immune homeostasis, metabolic balance, and therapeutic outcomes. Atopic dermatitis (AD), a chronic inflammatory skin disease, is closely linked to gut microbial dysbiosis. Traditionally regarded as a...