Kyoto Women's University

From intersection names to street rankings in Kyoto: Comparing ranking methods for incomplete pairwise data

Rankings constructed from incomplete pairwise comparisons may depend on the method used, yet applied studies often report a single ordering without quantifying disagreement among methods. Kyoto’s intersection names provide both a methodological example and a subject of broad publ...

Predictors of weight regain after weight loss in obesity: roles of birthweight, diet, and metabolic factors

Weight regain after weight loss is common in obesity. However, risk factors for weight regain remain uncertain, particularly with respect to developmental and dietary factors. This study aims to identify clinical, metabolic, developmental, and dietary predictors of weight regain....

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...

A genotype-first approach reveals the molecular basis of pyrin inflammasome activation

Mutations in the MEFV gene, which encodes pyrin, are associated with a spectrum of inflammatory conditions called pyrin-associated autoinflammatory diseases (PAADs). Of the 400 MEFV variants listed in the Infevers database, most are classified as variants of uncertain significanc...