Kyoto University of Advanced Science

Carbohydrate-to-fat ratio is positively associated with comprehensive frailty across protein-intake levels in older adults

Abstract Purpose Diet influences frailty, and protein intake has been a prime focus of prevention. However, frailty remains prevalent, even among older adults with relatively high protein intake, suggesting the influence of remaining energy distribution between carbohydrates and...

Triangulating Evidence on Serum Uric Acid and Cancer Risk: Consistent Inverse Associations With Lung Cancer

ABSTRACT We examined the association between serum uric acid (UA) levels and cancer incidence through a conventional observational and two‐sample Mendelian randomization (MR) study in the same population (triangulation). We followed 13,695 individuals aged 35–69 years for cancer...

Long‐term effects of tofogliflozin on renal function in patients with type 2 diabetes: A retrospective multicenter study

ABSTRACT Aims To investigate the long‐term renal effects of tofogliflozin, with the shortest half‐life among sodium–glucose cotransporter 2 inhibitors, in real‐world clinical practice. Materials and methods We retrospectively enrolled patients with type 2 diabetes mellitus treate...

Enzymatic Hydrogen Cyanide Release from Mandelonitrile Esters in Oribatid Mites

Abstract Arthropods use chemical defenses against predators by releasing toxic or repellent compounds from specialized exocrine glands. Oribatulid mites (Oribatida: Oribatulidae) contain mandelonitrile hexanoate (MNH); when they are subjected to physical stimuli, MNH decomposes t...