Kyoto Prefectural University of Medicine

Intravenous leiomyomatosis with marked edematous degeneration mimicking IVC thrombus: A case report

Intravenous leiomyomatosis (IVL) is a rare variant of leiomyoma characterized by proliferation of smooth muscle cells within uterine veins, with potential extension into the inferior vena cava (IVC), right atrium, or even pulmonary arteries. In advanced stages, IVL can lead to li...

Olive Oil Before Oral Glucose Delays Gastric Emptying and Lowers Glycemia Through Partially Redundant Glucagon and GLP-1 Signaling in Mice

Consumption of fat before carbohydrate (preload) attenuates postprandial glucose excursions, although the underlying mechanisms remain unclear. We investigated whether an olive oil preload (OG) reduces glycemia by engaging endocrine and neural regulation of gastric emptying. Wild...

A Totally Laparoscopic Transhiatal Approach for Esophageal Cancer During Mediastinoscopic Esophagectomy

Background: Mediastinoscopic esophagectomy is a minimally invasive approach that avoids thoracotomy and single-lung ventilation. We previously performed this procedure using hand-assisted laparoscopic surgery (HALS) and recently established a totally laparoscopic transhiatal appr...

A multicenter multistate modeling on the natural history of liver decompensation: Longitudinal analysis of 1777 patients.

BACKGROUND: Cirrhosis often remains silent until decompensation, after which survival deteriorates sharply. Contemporary, transition-aware estimates are limited, especially in Asian-predominant cohorts. We analyzed trajectories from compensated advanced chronic liver disease (cAC...

Ginsenoside Rd promotes the expression of acetylated α-tubulin and FOXJ1 in human bronchial epithelial cells

Mucociliary clearance is an airway defense mechanism driven by the coordinated function of mucus and motile cilia. Although ciliary beat frequency (CBF) reflects the motile function of ciliated cells, the generation and maintenance of ciliated cells are also essential for sustain...

Safety and Efficacy of Mature Cultured Corneal Endothelial Cell Therapy (Vyznova) in Eyes With Declining Long-term Efficacy After Prototype Cell Transplantation

Purpose: To report the efficacy and safety of mature cultured corneal endothelial cell (CEC) transplantation using neltependocel combined with the Rho kinase inhibitor Y-27632 (Vyznova) in eyes with declining long-term efficacy after transplantation of immature cultured CECs (pro...

Bayesian Power‐Based Sample Size Determination for Diagnostic Accuracy Studies

ABSTRACT In diagnostic accuracy studies, it is crucial to estimate the required sample size beforehand for the appropriate evaluation of diagnostic measures (e.g., sensitivity and/or specificity). In the development of pharmaceuticals and medical devices, although frequentist app...

Triangulating Evidence on Serum Uric Acid and Cancer Risk: Consistent Inverse Associations With Lung Cancer

ABSTRACT We examined the association between serum uric acid (UA) levels and cancer incidence through a conventional observational and two‐sample Mendelian randomization (MR) study in the same population (triangulation). We followed 13,695 individuals aged 35–69 years for cancer...

Long‐term effects of tofogliflozin on renal function in patients with type 2 diabetes: A retrospective multicenter study

ABSTRACT Aims To investigate the long‐term renal effects of tofogliflozin, with the shortest half‐life among sodium–glucose cotransporter 2 inhibitors, in real‐world clinical practice. Materials and methods We retrospectively enrolled patients with type 2 diabetes mellitus treate...

Optimization of coarsened exact matching through random forest classification

Abstract Background Coarsened exact matching (CEM) was developed to resolve the “matching paradox” in propensity score matching (PSM), where narrower caliper widths can paradoxically worsen covariate balance. However, its application to complex medical data faces practical challe...

Association between place of death and regional variation in senility mortality in Japan: a nationwide ecological study

Abstract Background In recent years, senility mortality has increased substantially in Japan, accounting for 12.9% of all deaths in 2024. Although senility (International Classification of Diseases, Tenth Revision, code R54) is often regarded as a non-specific cause of death in i...

Short‐Term Changes in General and Central Adiposity and Subsequent Cardiometabolic Risk in Japanese Adults Undergoing Routine Health Screening

ABSTRACT Objective Annual health screening provides repeated measurements of body mass index (BMI) and waist‐based indices, but the implications of short‐term changes in general and central adiposity for cardiometabolic risk remain unclear. We examined whether 1‐year changes in B...

Pneumonitis in Older Patients With Non-squamous Non-small Cell Lung Cancer Treated With Pembrolizumab and Pemetrexed

Background/Aim: Pembrolizumab combined with pemetrexed is efficacious in older patients with metastatic non-squamous non-small cell lung cancer (NSCLC) and a PD-L1 tumor proportion score (TPS) of <50%. However, treatment-related pneumonitis is concerning, and its impact on clinic...

The limitations of radiological protection in the Fukushima nuclear accident from the citizens’ perspectives: towards a revision of the general recommendations

The aim of this research is to identify the radiological protection problems after the Fukushima accident from the citizens’ perspective and to clarify the major points which should be included in the revised General Recommendations. As research methods, both qualitative and quan...

11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress

Abstract Glucocorticoids (GCs) have been proposed as maternal-fetal communication signals. However, fetal circadian rhythms are initially shielded from maternal entrainment, in addition to delayed circadian clock emergence due to CLOCK suppression. Premature CLOCK/BMAL1 activatio...

P1.112. Low Circulating miR-5193 Promotes PD-L1–mediated Immune Evasion and Predicts Immune Checkpoint Inhibitor Response in Esophageal Cancer

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Low levels of circulating tumor-suppressor microRNAs are associated with cancer progression and poor prognosis. However, their role in immune evasion and response to immune checkpoint inhibitors (ICIs) remai...

P1.110. Overexpression of DTL Relates to Tumor Cell Proliferation and Malignant Outcome of Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Comparative genomic hybridization (CGH) method has contributed to the analysis of amplification and deletion of various genes. We detected Denticleless E3 ubiquitin protein ligase homolog (DTL) using the Agi...

P1.182. Development of Difficulty Prediction Method for Mediastinoscopic Esophagectomy in Esophageal Cancer

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Mediastinoscopic esophagectomy is a minimally invasive procedure for esophageal cancer, but no established method exists to predict surgical difficulty. This study aimed to identify a difficulty...

P1.215. Segmental Loss of Signal on Continuous Intraoperative Nerve Monitoring Predicts Postoperative Pneumonia After Transmediastinal Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Recurrent laryngeal nerve paralysis (RLNP) is a well-known risk factor for postoperative pneumonia in esophageal cancer surgery. Transmediastinal esophagectomy,...

Immediate changes in trunk extension and pain following a structured exercise program in high school baseball players with extension-type low back pain: a retrospective observational study

Abstract Background Extension-type low back pain (LBP) is common among baseball players, but immediate exercise responses may differ among athletes. Evidence on exercise-specific acute responses in adolescent athletes remains limited. This retrospective observational study examin...