Kyoto Prefectural University

Olive Oil Before Oral Glucose Delays Gastric Emptying and Lowers Glycemia Through Partially Redundant Glucagon and GLP-1 Signaling in Mice

Consumption of fat before carbohydrate (preload) attenuates postprandial glucose excursions, although the underlying mechanisms remain unclear. We investigated whether an olive oil preload (OG) reduces glycemia by engaging endocrine and neural regulation of gastric emptying. Wild...

2-Aminoisobutylic Acid-Stabilized Helical Peptides for Selective Mitochondrial Gene Delivery

Abstract Efficient gene delivery to mitochondria remains a major challenge in the development of organelle-targeted therapeutics. Here, we report the rational design and evaluation of helix stabilized mitochondria-targeting peptides (MTPs) via the incorporation of 2-aminoisobutyr...

REAP1/AtSWAP70 integrates RAB5 and ROP signalling during sexual reproduction

Small GTPases of the Ras superfamily are critical regulators of diverse cellular processes. While crosstalk between their signalling pathways has been documented in animals, similar mechanisms remain unexplored in plants, where small GTPases have undergone unique evolutionary div...

Exploratory analysis of the associations of short-chain fatty acids and their related factors with growth performance in growing pigs using a Bayesian network

We suggested the causal relationships between daily weight gains (DG) and feed conversion ratios (FCR) of growing pigs, and short-chain fatty acids (SCFA) concentrations in digesta and blood, and SCFA-related factors such as intestinal morphology, SCFA transporters and tight junc...

High-temperature-treated soy protein isolate reduces amino acid availability and alters social novelty in mice

Abstract High-temperature (HT) treatments above 100 °C are important in food processing; however, their effects on the nutritional value of moist heat-treated proteins are less understood. Therefore, this study examined the impact of HT at 121 °C on soy protein isolate (SPI) in w...

Anti-gicerin Antibody Suppresses Early Pulmonary Metastatic Colonization of B16F10 Melanoma Cells

Background/Aim: Adhesion of circulating melanoma cells to the pulmonary vascular bed is a critical early step in hematogenous metastasis. Gicerin is an immunoglobulin superfamily cell adhesion molecule that can mediate homophilic cell-cell adhesion. We examined whether gicerin is...

The limitations of radiological protection in the Fukushima nuclear accident from the citizens’ perspectives: towards a revision of the general recommendations

The aim of this research is to identify the radiological protection problems after the Fukushima accident from the citizens’ perspective and to clarify the major points which should be included in the revised General Recommendations. As research methods, both qualitative and quan...

11β-HSD2 buffers fetal glucocorticoid exposure inducing Per1 expression under maternal stress

Abstract Glucocorticoids (GCs) have been proposed as maternal-fetal communication signals. However, fetal circadian rhythms are initially shielded from maternal entrainment, in addition to delayed circadian clock emergence due to CLOCK suppression. Premature CLOCK/BMAL1 activatio...

P1.112. Low Circulating miR-5193 Promotes PD-L1–mediated Immune Evasion and Predicts Immune Checkpoint Inhibitor Response in Esophageal Cancer

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Low levels of circulating tumor-suppressor microRNAs are associated with cancer progression and poor prognosis. However, their role in immune evasion and response to immune checkpoint inhibitors (ICIs) remai...

P1.110. Overexpression of DTL Relates to Tumor Cell Proliferation and Malignant Outcome of Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Comparative genomic hybridization (CGH) method has contributed to the analysis of amplification and deletion of various genes. We detected Denticleless E3 ubiquitin protein ligase homolog (DTL) using the Agi...

2-arm-PEG-OligocationsTransiently Shield theLiver Sinusoids to Mitigate Off-Target Hepatic Expression of mRNALipid Nanoparticles

ABSTRACT Ionizable lipid nanoparticles (iLNPs) are powerful platforms for mRNA-based vaccines and immunotherapies; however, their intrinsic liver tropism compromises both safety and efficacy. Off-target hepatic protein expression from delivered mRNA raises safety concerns, and he...

Measurements of Japanese cedar growth on rough surface using spectral imaging analysis

Abstract Accurate measurement of tree-ring increments on rough wood surfaces in the field is essential for evaluating forest productivity and merchantability. Conventional imaging approaches are hindered by intensity non-uniformity across the cross-section, particularly between t...