Kyoto Prefectural University

P1.110. Overexpression of DTL Relates to Tumor Cell Proliferation and Malignant Outcome of Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Comparative genomic hybridization (CGH) method has contributed to the analysis of amplification and deletion of various genes. We detected Denticleless E3 ubiquitin protein ligase homolog (DTL) using the Agi...

P1.112. Low Circulating miR-5193 Promotes PD-L1–mediated Immune Evasion and Predicts Immune Checkpoint Inhibitor Response in Esophageal Cancer

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Low levels of circulating tumor-suppressor microRNAs are associated with cancer progression and poor prognosis. However, their role in immune evasion and response to immune checkpoint inhibitors (ICIs) remai...

2-arm-PEG-OligocationsTransiently Shield theLiver Sinusoids to Mitigate Off-Target Hepatic Expression of mRNALipid Nanoparticles

ABSTRACT Ionizable lipid nanoparticles (iLNPs) are powerful platforms for mRNA-based vaccines and immunotherapies; however, their intrinsic liver tropism compromises both safety and efficacy. Off-target hepatic protein expression from delivered mRNA raises safety concerns, and he...

Measurements of Japanese cedar growth on rough surface using spectral imaging analysis

Abstract Accurate measurement of tree-ring increments on rough wood surfaces in the field is essential for evaluating forest productivity and merchantability. Conventional imaging approaches are hindered by intensity non-uniformity across the cross-section, particularly between t...