Kyoto Pharmaceutical University

Potent Antivirals for Respiratory Syncytial Virus Detected via Peptide-Based Fusion Inhibitor Screening

Abstract The respiratory syncytial virus (RSV) causes fatal pneumonia in neonates, infants, and older adults. However, no approved antiviral drugs exist for RSV; furthermore, the currently available antibody-based therapies are expensive and do not provide complete protection aga...

Ginsenoside Rd promotes the expression of acetylated α-tubulin and FOXJ1 in human bronchial epithelial cells

Mucociliary clearance is an airway defense mechanism driven by the coordinated function of mucus and motile cilia. Although ciliary beat frequency (CBF) reflects the motile function of ciliated cells, the generation and maintenance of ciliated cells are also essential for sustain...

Pathogenicity and intestinal barrier disruptive ability of Malassezia furfur in an alternative model host Caenorhabditis elegans is partially alleviated by Lacticaseibacillus rhamnosus

Abstract Malassezia furfur is fungi associated with various diseases; however, the mechanisms underlying its pathogenicity and the relationship between probiotics and fungi remain largely unknown. In the present study, Caenorhabditis elegans was used as the model host to evaluate...

BSFT-like action from cohomomorphism

Abstract By performing a field redefinition via a cohomomorphism on the Maurer-Cartan action of the A∞ algebra, we construct an action that reproduces the characteristic structure of boundary string field theory (BSFT), which we refer to as the BSFT-like action. We show that the...