Kyoto Medical Center

Carbonic anhydrase VIII regulates IP3R1-dependent Ca 2+ signaling to coordinate insulin secretion and hepatic glucose production

Intracellular Ca 2+ signaling is essential for glucose-induced insulin secretion (GIIS) and hepatic glucose production (HGP), yet how Ca 2+ dynamics are coordinated across organs remains unclear. Carbonic anhydrase VIII (CA8), an endogenous inhibitor of inositol 1,4,5-trisphospha...

Botulinum Toxin Therapy for Diseases in the Oral and Maxillofacial Regions: Current Evidence and Future Perspectives

Botulinum neurotoxin (BoNT) therapy has developed from a treatment primarily used for neurological disorders into a versatile therapeutic modality applied across a broad range of medical and dental conditions [...]

Community periodontal index based screening findings and healthcare expenditures: a 7-year cohort study of male employees in Japan

Abstract Background The global economic burden of dental diseases, particularly periodontitis, is substantial, with growing evidence linking these conditions to systemic diseases such as diabetes and cardiovascular diseases. Although international studies have demonstrated that p...

Predictors of weight regain after weight loss in obesity: roles of birthweight, diet, and metabolic factors

Weight regain after weight loss is common in obesity. However, risk factors for weight regain remain uncertain, particularly with respect to developmental and dietary factors. This study aims to identify clinical, metabolic, developmental, and dietary predictors of weight regain....

Insulin Dosing Is Associated With Cardiac Sympathetic Predominance Independent of Glycemic Profiles in Type 1 Diabetes Under Free-Living Conditions

While insulin activates the sympathetic nervous system in experimental settings, whether therapeutic insulin administration is associated with cardiac sympathetic predominance under free-living conditions remains unclear. This prospective observational study investigated the asso...

Comparison of response criteria in palliative radiotherapy for bleeding gastric cancer: A secondary analysis of the JROSG 17-3 multicenter prospective observational study

PURPOSE: In radiotherapy for bleeding gastric cancer, no standard response definition exists; studies have used transfusion-only or transfusion-plus-hemoglobin criteria. After inter-facility transfer or during home care-sometimes following palliative radiotherapy-laboratory resul...

Clinical significance of inhaled COPD therapy in advanced or recurrent non-small cell lung cancer in the immune checkpoint inhibitor era: a multicenter retrospective cohort study

Immune checkpoint inhibitors (ICIs) have markedly improved survival in advanced non–small cell lung cancer (NSCLC), potentially modifying the prognostic impact of comorbid chronic obstructive pulmonary disease (COPD). We conducted a multicenter retrospective cohort study across f...

Smartphone-measured heart rate variability and quality of life in patients with gynecological cancer: a multicenter prospective study

In this study, we aimed to investigate the association between heart rate variability (HRV) and quality of life (QoL) in patients with gynecological cancer and examine whether continuous HRV monitoring may help identify QoL deterioration. This multicenter, prospective, observatio...

Algorithm for classifying the underlying pathologies in postpartum hemorrhage using bleeding rate, fibrinogen, and fibrin/fibrinogen degradation products: a case series study

Abstract Background Understanding patients’ underlying pathologies is essential for appropriate treatment during postpartum hemorrhage (PPH) management. The objective of this study is to develop an algorithm that quantitatively classifies the underlying pathologies in PPH using c...

Immediate changes in trunk extension and pain following a structured exercise program in high school baseball players with extension-type low back pain: a retrospective observational study

Abstract Background Extension-type low back pain (LBP) is common among baseball players, but immediate exercise responses may differ among athletes. Evidence on exercise-specific acute responses in adolescent athletes remains limited. This retrospective observational study examin...