Kyoto Katsura Hospital

Guest-Induced Chirality Transfer in Trimers of Invertible Cylinder-Shaped Macrocycles

Abstract Transfer of chiral information is abundant in biological processes. To mimic them in artificial systems, chiral macrocyclic molecules are particularly promising components for their simplicity and easy-to-predict intermolecular interactions. Herein, we report a chirality...

2026 revised CVIT clinical expert consensus on drug coated balloons for coronary artery disease

Abstract Drug-coated balloons (DCBs) are attracting attention as a therapeutic alternative to drug-eluting stents (DES) in percutaneous coronary interventions. DCB technology allows direct delivery of antiproliferative drugs to the vessel wall without implantation of a permanent...

2-Aminoisobutylic Acid-Stabilized Helical Peptides for Selective Mitochondrial Gene Delivery

Abstract Efficient gene delivery to mitochondria remains a major challenge in the development of organelle-targeted therapeutics. Here, we report the rational design and evaluation of helix stabilized mitochondria-targeting peptides (MTPs) via the incorporation of 2-aminoisobutyr...

Development of a UV-Responsive Fusion Peptide Combining a Cell-Penetrating and a Mitochondria-Targeting Peptide to Suppress Intracellular Off-Target Effects

Abstract Modification of plant mitochondria has attracted increasing attention as a strategy for developing highly productive crops, driving efforts to achieve efficient mitochondrial delivery of cargos. Mitochondria-targeting gene carriers with a strong cell-penetrating ability...

Cluster‐Defined Response Patterns Following Pain Neuroscience Education With Physical Activity in Older Women With Chronic Low Back Pain: A Quasi‐Randomized Exploratory Study

ABSTRACT Background and Aims To explore patterns of treatment response to pain neuroscience education combined with physical activity (PNE‐PA) and to examine baseline characteristics associated with these patterns in older women with chronic low back pain (CLBP). Methods In a com...

Transplant outcomes after intensive chemotherapy or venetoclax plus azacitidine in acute myeloid leukemia: a multicenter retrospective study in Japan

The present retrospective multicenter study in Japan evaluated the role of venetoclax plus azacitidine (V/A) before first allogeneic hematopoietic stem cell transplantation (SCT) in 144 transplant-eligible acute myeloid leukemia (AML). Thirty-seven patients received V/A prior to...

Thermophysical characterization of amorphous NiTa thin films for heat-assisted magnetic recording using frequency-domain thermoreflectance

The rapid global growth in data volume has intensified the need to increase the recording density of hard disk drives (HDDs) while reducing storage costs. Heat-assisted magnetic recording (HAMR), a next-generation HDD technology based on laser-induced heating, requires accurate t...

Structural evolution and thermophysical properties of Tb3ScxAl5-xO12 melts via AIMD and aerodynamic levitation

High-power magneto-optical devices based on terbium garnet crystals require materials with high thermal stability and excellent optical performance. However, their growth is often hindered by instability in high-temperature melts. Here, we combine ab initio molecular dynamics (AI...

Insulin Dosing Is Associated With Cardiac Sympathetic Predominance Independent of Glycemic Profiles in Type 1 Diabetes Under Free-Living Conditions

While insulin activates the sympathetic nervous system in experimental settings, whether therapeutic insulin administration is associated with cardiac sympathetic predominance under free-living conditions remains unclear. This prospective observational study investigated the asso...

Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS / BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial

The randomized phase II DEEPER trial (jRCTs061180022) previously reported superior depth of response with modified 5-fluorouracil, leucovorin, oxaliplatin and irinotecan (m-FOLFOXIRI) plus cetuximab versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer (m...

Clinical significance of inhaled COPD therapy in advanced or recurrent non-small cell lung cancer in the immune checkpoint inhibitor era: a multicenter retrospective cohort study

Immune checkpoint inhibitors (ICIs) have markedly improved survival in advanced non–small cell lung cancer (NSCLC), potentially modifying the prognostic impact of comorbid chronic obstructive pulmonary disease (COPD). We conducted a multicenter retrospective cohort study across f...