Institution
Kurchatov Institute
Recent research
- Health & MedicineOpen access
Cellular and Tissue Mechanisms of Laser-Assisted Regeneration of Tympanic Membrane Perforation
Chronic tympanic membrane (TM) perforations remain a significant clinical problem due to limited spontaneous healing and the drawbacks of surgical interventions. The present study aimed to evaluate the effects of low-intensity infrared laser irradiation on cellular mechanisms of...
- Climate & EnvironmentOpen access
Atmospheric pollution by fine particulate matter (PM2.5) poses a severe threat to public health in industrial regions of Kazakhstan, such as Ust-Kamenogorsk and Pavlodar, where a sharp continental climate exacerbates toxic element accumulation. This study aimed to compare the ele...
- Engineering & TechnologyOpen access
Gas sensor properties of CuGa2O4-based nanocomposites: role of phase composition and microstructure
Practical implementation of machine olfaction and electronic nose systems requires gas-sensing materials with excellent long-term stability for reliable operation in sensor arrays. Promising in this regard nanocrystalline CuGa 2 O 4 -based materials were synthesized by flame spra...
- Materials & EnergyOpen access
Developing nanoformulations of antitumor drugs represents a critical priority in addressing key challenges of free drug administration such as low therapeutic efficacy, poor bioavailability, and severe side effects, including high systemic toxicity. In this study, mPEG-b-PCL bloc...
- Materials & EnergyOpen access
Effect of copper state on the properties of CuOx/TiO2 catalysts for low-temperature CO oxidation
A comprehensive study of supported CuO x /TiO 2 catalysts for low-temperature oxidation of carbon monoxide was conducted. The composition, structure, morphology, electronic state of the active phase for the samples were studied depending on calcination temperature and copper load...
- Engineering & Technology
Abstract A novel technique for the absolute calibration of ionization chambers measuring the intensity of extracted carbon ion beams in the 400–450 MeV/nucleon energy range using activation detectors has been proposed at the Institute for High Energy Physics of the National Resea...
- BiologyOpen access
Cryo-EM structure of ex vivo Sup35 yeast prion and the factors defining prion phenotype
Abstract Human prions and amyloids exhibit structural diversity that correlates with different pathological manifestations. Yeast prions represent a convenient model for studying fundamental properties of prions and their strain diversity. The Sup35 yeast prion has multiple struc...
- Physics & SpaceOpen access
Abstract A rigorous statistical analysis of Regge-type trajectories for light non-strange meson mass spectra is carried out, which explicitly accounts for experimental uncertainties. We test three scenarios: a linear model with distinct radial ( n ) and orbital ( l ) slopes (Mode...
- Materials & Energy
The Spall Strength of the Polytetrafluoroethylene Irradiated above the Melting Point
The features of the deformation and fracture of polytetrafluoroethylene (PTFE) before and after exposure to gamma radiation above the melting point of the crystalline phase are investigated using shock wave loading methods at various impact velocities from 100 to 600 m/s, which c...
- Engineering & TechnologyOpen access
Residual stresses pose a significant challenge in additive manufacturing, particularly for large metal parts. Monitoring these stresses is essential to achieving reliable performance characteristics. Neutron diffraction—a nondestructive method that measures residual stresses thro...
- Health & Medicine
Comparative Anatomy of the Central Nervous System of Danio Rerio and Mammals
Abstract To date, the Danio rerio has become one of the most popular model organisms in biomedical research, particularly for studying pathologies of the nervous system. Its widespread use is driven by several key advantages: external fertilization, high fecundity, rapid embryoni...
- Health & Medicine
Abstract Astaxanthin is a high-value carotenoid used in nutrition, cosmetics, pharmaceuticals, and biotechnology, but its poor water dispersibility and oxidative stability limit its formulation. Here, we engineered yeast Yarrowia lipolytica for the efficient production of glycosy...
- Engineering & Technology
Abstract A method for forming highly porous poly(3,4-ethylenedioxythiophene) polystyrenesulfonate (PEDOT:PSS) composite particles with an excess nonconductive PSS component via spraying into liquid nitrogen, followed by freeze-drying, was proposed. The additional PSS content both...
- AI & ComputingOpen access
Conformal blocks of Wess-Zumino-Witten model from its free-field representation
A bstract A powerful approach to the celebrated Wess-Zumino-Witten (WZW) model is provided by its free-field realization. However, explicit calculations of conformal blocks are not described in the literature in full detail. We begin this study with the simplest cases of the $$ \...
- BiologyOpen access
Soybean (Glycine max (L.) Merr.) is one of the most widely cultivated grain legumes worldwide. A genetic analysis of soybean samples around the world is essential for effective breeding programs and the development of genomic and marker-assisted selection. This study investigated...
- Health & MedicineOpen access
Co-Mutation of CREBBP/EP300 and POLE/POLD1 Identifies a TMB-High Subset of MSS CRC
Identifying immunotherapy biomarkers for colorectal cancer (CRC) beyond MSI-high status is challenging. We evaluated CREBBP/EP300 and POLE/POLD1 mutations as candidate markers using public cohorts (MSK-CHORD, n = 5493; TCGA, n = 528; MetTropism, n = 24,496; ICI-treated, n = 1610)...