Kuopio University Hospital

SOX10 Expression in Primary Salivary Gland Tumors: A Meta-Analysis

Abstract Purpose Primary salivary gland tumors form a heterogeneous group with diagnostic challenges. Sex-determining region Y-related homeobox 10 (SOX10) is a transcription factor studied in primary salivary gland tumors for over a decade. To date, no systematic review or meta-a...

Nicotine pouch use induces alterations in salivary metabolites and metabolic pathways. Preliminary study based on NMR spectroscopy

Abstract Introduction Nicotine, a addictive substance in tobacco products, has profound negative impacts on oral and systemic health. This study aims to investigate salivary metabolites and metabolic pathways in nicotine pouch users. Methods This study included 28 participants. O...

Cesarean delivery is associated with atopic sensitization to inhalants but not food at age 5

Abstract Purpose Intrauterine and early neonatal exposures, including maternal, obstetric, and postnatal factors, may influence the risk of atopic sensitization in offspring. However, their independent associations with inhalant and food sensitization remain underexplored. Method...

Comparison of robotic-assisted and manual cochlear implant electrode array insertions considering cochlear geometric factors

Abstract Purpose Purpose of the present study was to compare the intracochlear trauma coincidentally caused by robotic-assisted and manual cochlear implant electrode array insertions in human temporal bones, and to evaluate the influence of cochlear geometry on insertion outcomes...

The Kuopio Idiopathic Normal Pressure Hydrocephalus Protocol Revisited: The Predictive Value of Cerebrospinal Fluid Tap Test

BACKGROUND AND OBJECTIVES: Idiopathic normal pressure hydrocephalus is a condition with gait impairment, incontinence, and cognitive decline, treated with shunt surgery. The Gothenburg scale (GBS) provides comprehensive assessment of symptoms and outcomes. The cerebrospinal fluid...

Interstitial Fluid Load Support in Human Articular Cartilage: Effects of Degeneration, Loading, and Material Properties via Combined Experimental Testing and Computational Modeling

Abstract Interstitial fluid pressurization plays a key role in cartilage mechanics, as it enables load support, reduces solid matrix stress, and limits solid–solid contact, thereby minimizing wear and friction. Because direct measurement of interstitial fluid load support is chal...

Neuropathology of a patient with Parkinson's disease and biallelic expansion in RFC1

This is the first report of neuropathology in biallelic RFC1 expansion-associated Parkinson's disease (PD). It shows a synucleinopathy of intraneuronal Lewy bodies consistent with the clinical PD diagnosis while neuropathological CANVAS (Cerebellar Ataxia with Neuropathy and bila...

Review of Hypoxemia Quantification Methods for Assessing the Severity of Obstructive Sleep Apnea

Abstract Purpose of Review Obstructive sleep apnea (OSA) is a common nocturnal breathing disorder characterized by recurrent upper airway obstruction during sleep, leading to sleep fragmentation and intermittent hypoxemia. The apnea-hypopnea index (AHI) is the most widely used cl...

Cervical facet nerve blockade improves head relocation accuracy for sagittal movements, shoulder joint relocation accuracy for shoulder abduction and standing balance in patients with chronic cervical pain

To investigate whether unilateral cervical facet nerve blockade (FNB) is associated with changes in head repositioning accuracy (HRA), shoulder joint relocation accuracy (JRA), and standing balance in patients with chronic neck pain. This retrospective single-center interventiona...

Pain and Analgesic Doses Versus Free Interleukin 18 (IL-18F) Blood Levels Following Surgery: A Prospective Randomized Study of Patients With Minilaparotomy Cholecystectomy Versus Laparoscopic Cholecystectomy

Background/Aim: Cytokines (CYT) are regulators of the acute phase immune response (APR) to inflammation and trauma. The purpose of this work was to assess blood level correlations of various CYTs; interleukin-18 (IL-18), IL-18 binding protein (IL-18BP), free interleukin 18 (IL-18...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

The Incidence of Sensorineural Hearing Loss Diagnoses in People with and without Parkinson's Disease

Abstract Background Parkinson's disease (PD) and sensorineural hearing loss (SNHL) are both prevalent conditions among older adults. Although increasing number of studies have investigated SNHL as a risk factor for PD, it is not well known how diagnosed PD affects the likelihood...

Long-term type 2 diabetes risk prediction using machine learning with childhood, adolescent, and genetic factors

Abstract Late diagnosis of type 2 diabetes increases patient morbidity and healthcare burden, yet current prediction models use adult risk factors to estimate 5–10-year risk. In this manuscript, we evaluate long-term prediction of type 2 diabetes over 38 years using childhood fac...