Kumamoto University Hospital

Fourth-generation chimeric antigen receptor T cells targeting mucin 1 for enhanced anti-tumor activity against breast cancer

Breast cancer (BC) is the leading cause of cancer-related mortality worldwide, and current treatments are unmet clinical needs. Although chimeric antigen receptor (CAR) T cells have been approved for hematological malignancies, their advancements in solid tumors are challenging....

Telomere variant sequences encode the genetic blueprint for allele-specific telomere length

The ends of human chromosomes are capped by specialized nucleoprotein structures, termed telomeres, which are essential for genome stability. Recent advances in long-read sequencing have enabled allele-specific telomere length measurements at nucleotide resolution, uncovering ext...

Angioarchitectural characterization of transdural supply in brain arteriovenous malformations: a multicenter retrospective study

Transdural supply (TDS) is a recognized angioarchitectural feature of brain arteriovenous malformations (bAVMs). We aimed to systematically characterize the angioarchitecture of TDS in bAVMs, focusing on whether transdural feeders terminated within the nidus or connected directly...

Post-obligation physician retention among Jichi Medical University graduates in Okinawa prefecture, Japan: a descriptive comparative study of the Kyushu region

Abstract Background Global strategies to address physician maldistribution include recruiting students with rural backgrounds, community-based training, bonded service, financial incentives, and personal and professional support. However, retention after obligatory service remain...

Discovery of Bis-ThioureaDerivatives as Human DNATopoisomerase IIα Inhibitors with Potent Anticancer Effects

Abstract DNA topoisomerase IIα (Topo IIα) is essential for maintaining genomic stability during DNA replication and mitosis and is highly expressed in cancer cells, making it a promising target for anticancer therapy. In this study, bis-thiourea derivatives were investigated for...

Relationship between initial dose, dose intensity, and survival in unresectable pancreatic cancer treated with nanoliposomal irinotecan, fluorouracil, and folinic acid

Abstract While nanoliposomal irinotecan with fluorouracil and folinic acid (NFF) is a standard second-line regimen for unresectable pancreatic cancer (uPC) after gemcitabine-based therapy, the effects of initial dosing and relative dose intensity (RDI) in routine practice are unc...

Integrated Pharmacokinetic Assessment and Individualized Dosing in Pediatric Critical Care

Optimizing pharmacotherapy in pediatric intensive care requires an integrated understanding of developmental physiology and critical illness-related pathophysiology. Drug exposure in children cannot be interpreted as a simple scaled version of adult pharmacokinetics. Critically i...

Element-SpecificSensitivity of Lanthanoid Ions toChiral Crystal Fields in K3[Ln2(NO3)9] Probed by 4f–4f Circular Dichroism

Abstract For chiral inorganic crystals composed of achiral components, chiral crystal fields around metal ions are expected to play a key role in the emergence of chiroptical properties. Circular dichroism (CD) spectra can serve as useful probes of such chiral crystal fields. Her...

Change in the prognostic utility of regional left ventricular longitudinal strain values in patients undergoing transcatheter aortic valve implantation

BACKGROUND: To evaluate the difference in prognostic utility of echocardiographic parameters between pre- and post-transcatheter aortic valve implantation (TAVI) periods. METHODS AND RESULTS: This study enrolled 189 patients who underwent TAVI at Kumamoto University Hospital betw...