Kumamoto Orthopedic Surgery Hospital

Prior vedolizumab exposure and fibroblast-derived MMP13 are associated with ustekinumab nonresponse in ulcerative colitis

Abstract Background As therapeutic options for ulcerative colitis increase, optimizing the sequencing of advanced therapies has become an important challenge. We examined whether baseline clinical characteristics influence the effectiveness of ustekinumab and investigated molecul...

Impact of Circumferential Calcification and Acquired Minimum Lumen Area on 1‐Year Primary Patency After Drug‐Coated Balloon Angioplasty for Femoropopliteal Lesions

BACKGROUND: Severe calcification predicts restenosis after drug-coated balloon (DCB) angioplasty for femoropopliteal lesions, but whether an adequate post-procedural minimum lumen area (MLA) can attenuate this effect, and how intravascular ultrasound (IVUS) circumferential calcif...

A Case of Cytokine Release Syndrome (CRS) Related to Treatment With Lenvatinib Plus Pembrolizumab for Metastatic Clear Cell Renal Cell Carcinoma

ABSTRACT Introduction Cytokine release syndrome (CRS) is a systemic inflammatory response triggered by various factors, including infection and immunotherapy. Due to its nonspecific presentation, distinguishing CRS from other life‐threatening conditions remains challenging. Case...