Institution
Krembil Research Institute
Recent research
- Health & MedicineOpen access
Purpose: To describe short- and long-term visual outcomes after MAIA microperimetry biofeedback training (BT) in a low-vision rehabilitation cohort. Methods: Retrospective study of patients who completed BT between 2017 and 2023 (4.1 ± 0.6 sessions). The MAIA device recorded P1 a...
- Health & Medicine
Antimalarial exposure and renal histopathologic findings in lupus nephritis
Abstract Objectives This study aimed to evaluate the association between antimalarial exposure and renal histopathologic findings at kidney biopsy in patients with lupus nephritis (LN). Methods This study was conducted within the University of Toronto Lupus Clinic cohort. To ensu...
- Health & MedicineOpen access
BACKGROUND: Restoring blood flow to ischemic tissue is the cornerstone of acute stroke therapy and is usually beneficial. However, when reperfusion is achieved for severely injured tissue, it is often futile and may occasionally cause harm. We aim to determine the prevalence and...
- Health & MedicineOpen access
Difficult-to-treat (D2T) systemic lupus erythematosus (SLE) is increasingly recognised in clinical practice but is still conceptually underdeveloped. In contrast to rheumatoid arthritis and psoriatic arthritis, for which formal D2T frameworks have been proposed, SLE still lacks a...
- BiologyOpen access
Neural dynamics underlying minute-timescale persistent behaviour in the human brain
Pursuing longer-term goals relies on representations of task context that can be maintained over long periods of time and switched flexibly when goals change. Little is known about the neural substrate for maintaining context representations on the minute-timescale on which human...
- Health & MedicineOpen access
Abstract Mesenchymal stromal cell (MSC) interactions with monocytes/macrophages are central to their therapeutic effects in knee osteoarthritis (KOA); however, mechanisms of these interactions are not fully understood. We hypothesize that MSC soluble factors, particularly interle...
- Health & Medicine
Background: Antibody-mediated rejection (AMR) is the main driver of late kidney allograft loss. Anti-HLA donor-specific antibodies (DSA) are strongly associated with AMR. However, 30-60% of DSA + patients do not develop AMR, raising the possibility of local tissue adaptations to...
- Health & Medicine
Objectives To identify potential causal biomarkers for obesity-related knee osteoarthritis (OB+OA+) by metabolome-wide association analysis (MWA) and Mendelian randomization (MR). Methods Four cohorts were included: the Newfoundland Osteoarthritis Study (NFOAS) as discovery, the...
- Health & Medicine
Clinical Relevance of Pelvic and Heel Enthesophytes in Psoriatic Arthritis
Objectives Enthesitis is a hallmark feature of psoriatic arthritis (PsA), but its clinical assessment can be confounded by subjective assessment and overlapping fibromyalgia. We aimed to investigate the clinical and functional associations of radiographic enthesophytes in a large...
- Health & Medicine
Objectives Overweight and obesity are associated with reduced odds of achieving minimal disease activity (MDA). Whether this effect is mediated by direct inflammation or psychosocial factors remains unclear. This study aimed to assess a) the influence of body mass index (BMI) on...
- BiologyOpen access
Hypothalamic recurrent inhibition regulates functional states of stress effector neurons
ABSTRACT Stress triggers rapid and reversible shifts in vital physiological functions from homeostatic operation to emergency response. However, the neural mechanisms regulating such functional stress states remain poorly understood. Here we identify a novel recurrent inhibitory...