Krembil Foundation

Cerebral Microbleeds and Superficial Siderosis: Vascular Correlates and Cognition in a Memory Clinic

OBJECTIVE: Cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS) are increasingly recognized in patients with cognitive impairment and are considered markers of cerebral small vessel disease and cerebral amyloid angiopathy (CAA). However, their associated variable...

Clinical Relevance of Pelvic and Heel Enthesophytes in Psoriatic Arthritis

Objectives Enthesitis is a hallmark feature of psoriatic arthritis (PsA), but its clinical assessment can be confounded by subjective assessment and overlapping fibromyalgia. We aimed to investigate the clinical and functional associations of radiographic enthesophytes in a large...

Acyl-Alkyl-Phosphatidylcholine C40:6 is Potentially a Causal Biomarker for Obesity-Related Knee Osteoarthritis: Data from 4 Independent Cohorts

Objectives To identify potential causal biomarkers for obesity-related knee osteoarthritis (OB+OA+) by metabolome-wide association analysis (MWA) and Mendelian randomization (MR). Methods Four cohorts were included: the Newfoundland Osteoarthritis Study (NFOAS) as discovery, the...

Differential Impact of Body Mass Index on Minimal Disease Activity Across Therapies in Psoriatic Arthritis

Objectives Overweight and obesity are associated with reduced odds of achieving minimal disease activity (MDA). Whether this effect is mediated by direct inflammation or psychosocial factors remains unclear. This study aimed to assess a) the influence of body mass index (BMI) on...

Hypothalamic recurrent inhibition regulates functional states of stress effector neurons

ABSTRACT Stress triggers rapid and reversible shifts in vital physiological functions from homeostatic operation to emergency response. However, the neural mechanisms regulating such functional stress states remain poorly understood. Here we identify a novel recurrent inhibitory...