KPJ Healthcare University

A single-centre study on the transformative impact of bariatric surgery on metabolic health in Malaysia

Introduction. Metabolic diseases such as obesity, type 2 diabetes, hypertension and dyslipidemia significantly contribute to the global public health burden. Bariatric surgery leads to substantial improvements in obesity and other metabolic diseases but most studies are based on...

Oncolytic virotherapy in cancer: cellular mechanisms, engineering strategies, and clinical translation

Abstract Oncolytic viruses (OVs) combine tumour-selective infection and replication with direct tumour-cell destruction and the capacity to induce antitumour immune responses. This review critically synthesises the cellular mechanisms, engineering strategies, preclinical developm...

Glucagon-Like Peptide-1 Receptor Agonists and Neovascular Age-Related Macular Degeneration in Type 2 Diabetes: A Review of Emerging Clinical Evidence

Abstract Purpose of Review Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used in the management of type 2 diabetes mellitus (T2DM) because of their established glycaemic, weight, cardiovascular, and kidney benefits. Recent observational evidence has raised...

Ferroptosis and Iron Dyshomeostasis as Drivers of Wound Chronicity in Diabetic Foot Ulcers: Pathophysiological Mechanisms and Targeted Therapeutic Strategies

Background diabetic foot ulcers (DFUs) carry 5-year mortality rates of 50%–70% and recurrence rates of 65% at three to five years. Standard-of-care protocols fail to resolve wound chronicity in a substantial proportion of patients, reflecting incomplete understanding of the cellu...