KPJ Ampang Puteri Specialist Hospital

Gut microbiome composition and plasma cytokines in acute leukaemia in relation to chemotherapy

Abstract Background: The gut microbiome and cytokines are involved in maintaining immune homeostasis and may influence the prognosis and complications experienced by acute leukaemia (AL) patients receiving chemotherapy. Methodology: This longitudinal study analysed blood and stoo...

Homologous Recombination Deficiency (HRD) and BRCA oncogenic variants in newly diagnosed advanced Epithelial Ovarian Cancer (EOC): first report among multi-ethnic patients

Ovarian cancer patients with homologous recombination deficiencies (HRD) exhibit specific clinical behaviours and improved responses to platinum-based chemotherapy and poly (ADP-ribose) polymerase treatment. HRD-positive patients are characterised by having genomic scar score (GS...