Korean Association Of Science and Technology Studies

Mosapride promotes internalization of a TREK1–HTR4 complex and exerts rapid antidepressant-like effects

Major depressive disorder (MDD) remains a critical global health burden, and a substantial proportion of patients exhibit insufficient responses to conventional monoaminergic antidepressants. Selective inhibition of the two-pore domain potassium channel TREK1 has emerged as a pro...