Korea Institute of Toxicology

Animal-origin-free medium enhances G2/M progression while maintaining identity and genomic stability in human adipose-derived MSCs

BACKGROUND: Mesenchymal stem cells (MSCs) are considered promising candidates for regenerative and immunomodulatory therapies. However, their clinical use requires xeno-free, good manufacturing practice (GMP)-compatible culture systems. Conventional serum-containing media (FCM) p...

Maternal dimethoxyethyl phthalate exposure enhances nicotine challenge-induced locomotor sensitization in adult male offspring rats: role of striatal dopamine D1 receptor

Early-life exposure to environmental endocrine disruptors, such as phthalates and bisphenol A, has been linked to neurobehavioral disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD). Recent studies have also reported that individuals...

Effects of starch type and concentration on the physicochemical, antioxidant, textural, and sensory properties of tomato juice-incorporated Gwapyeon

Abstract Gwapyeon is a molded Korean starch confection traditionally prepared by heating a fruit-derived liquid with starch and cooling the paste to form a cuttable gel. The present study examined whether a contemporary tomato-juice formulation could retain the inherited processi...

Optimizing the Structural Integrity of Gwapyeon with Red Bull Ⓡ and Enhancing Consumer Acceptability: A Comparison of Corn, Mung Bean, and Potato Starch

Gwapyeon, a traditional Korean fruit starch-based gel, offers a unique matrix for functional food diversification.This study investigated the technical feasibility of incorporating a commercial energy beverage (Red Bull Ⓡ ) into a gwapyeon system and evaluated how the source and...

KiGEP: a quantitative algorithm for calculating human kidney similarity and nephrotoxicity in human kidney organoids

Kidney organoids (KOs) are being actively developed and used as models for evaluating nephrotoxicity, which is an important process during drug development. To evaluate human pluripotent stem cell-derived KOs, various lineage markers have been used to confirm KO differentiation v...