Korea Institute of Sport Science

Latent profiles of body composition in older adults with hypertension: associations with physical fitness and differences in blood pressure and fasting plasma glucose

[Purpose] This study aimed to identify the body composition profiles of older adults with hypertension and examine their associations with physical fitness and cardiometabolic characteristics.[Methods] This cross-sectional study included 491 community-dwelling older adults with h...

Integrative ALS therapy: gene targeted therapy by base editing and potential exercise rehabilitation as synergistic strategies for functional recovery

[Purpose] A key pathological hallmark of amyotrophic lateral sclerosis (ALS) is transactive response DNA-binding protein 43 (TDP-43, encoded by TARDBP) proteinopathy. Mutations in TARDBP and cellular stress can drive nuclear clearance and cytoplasmic aggregation of TDP-43. TDP-43...