Korea Institute of Oriental Medicine

Metabolomic profiling and biomedical potential of adventitious roots derived from a 150-year-old mountain ginseng

Panax ginseng Meyer, sometimes known as Asian ginseng or Korean ginseng, is an important medicinal herb used in traditional medicine and health foods in Korea, China, and Japan. Ginsenosides, also known as saponins, are found in ginseng roots along with polysaccharides, peptides,...

Marine-Inspired Synergistic Adhesion Enables Highly Efficient and Atraumatic Macromolecular Transdermal Delivery on Dynamic Skin

Abstract Effective transdermal drug delivery (TDD) demands both the ability to bypass the stratum corneum (ST) and the robustness to sustain delivery efficiency under real-life conditions. Despite advances in nanocarriers, microneedles, and electrostimulation, many TDDS strategie...

Glycaemic–treatment phenotypes of diabetes and their correlates among Korean adults: a repeated cross-sectional analysis of the Korea National Health and Nutrition Examination Survey, 2015–2024

Existing studies of diabetes management have largely relied on dichotomous controlled/uncontrolled outcomes, which obscure the clinical heterogeneity of the population living with diabetes. We propose a composite classification combining HbA1c level and treatment stage, character...

Taxonomy-Guided Discovery of Antiviral Resources in Korean Peucedanum L. (Apiaceae)

The genus Peucedanum (Apiaceae) contains diverse coumarins and related secondary metabolites with a wide range of pharmacological activities; however, the antiviral potential of Korean taxa remains largely unexplored. In this study, we evaluated the cytotoxicity and anti-influenz...

Pattern-related profiles of acupuncture points for pain management

In Traditional East Asian Medicine, acupoints are selected based on clinical symptoms and pattern identification. Since treatment plans target specific diseases and patterns, acupoints may be selected based on clinical indications or pattern-related considerations. This study aim...

WDR23 prevents bone loss by promoting autophagic degradation of TRAF6 in osteoclastogenesis

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a pivotal adaptor molecule in the receptor activator of nuclear factor-κB (RANK) and its ligand (RANKL) signaling pathways, which are essential for osteoclastogenesis. In this study, we identified WD40 repeat-containin...

In vitro α-glucosidase and 15-lipoxygenase inhibitory, anticancer, and volatile metabolite properties of Aspilia africana and Warburgia ugandensis tissues

Aspilia africana (Pers.) C. D. Adams (Family Asteraceae) and Warburgia ugandensis Sprague (Family Canellacea) are widely used in African traditional medicine to treat diabetes mellitus (DM), inflammatory diseases, and prostate and breast cancers. However, their inhibitory effects...

Acupoint hot compress for labor-pain management: a randomized, parallel-group, controlled trial

Background Non-pharmacological pain management approaches, including acupoint hot compress, may provide valuable support for women dealing with pain during the latent stage of labor, but the evidence supporting this effect is limited. We investigated whether acupoint hot compress...