Korea Institute of Brain Science

The structural origin of irreversible transitions in biological networks

Cellular processes often exhibit irreversible state transitions even after external signals responsible for a transition are withdrawn. Long-standing questions remain: Where does such irreversibility originate from and can it be reversed? Although positive-feedback circuits among...

Mosapride promotes internalization of a TREK1–HTR4 complex and exerts rapid antidepressant-like effects

Major depressive disorder (MDD) remains a critical global health burden, and a substantial proportion of patients exhibit insufficient responses to conventional monoaminergic antidepressants. Selective inhibition of the two-pore domain potassium channel TREK1 has emerged as a pro...