Korea Disease Control and Prevention Agency

Integrative clinical–genomic modeling evaluates exploratory Non-APOE candidate signals in Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by a genetic architecture dominated by APOE , while predictive modeling in clinically enriched cohorts is often driven by neuropsychological and clinical variables. This combination limits the interpretability of secondary genetic signals...

Molecular evidence suggestive of transovarial transmission of severe fever with thrombocytopenia syndrome virus in chigger mites

Abstract Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease with high case-fatality rates in East Asia. While hard ticks are recognized as the primary vectors of SFTS virus (SFTSV), the detection of SFTSV RNA in chigger mites suggests their...

Seroprevalence of Toxoplasma gondii among animal-associated workers and companion animals in South Korea

Abstract Toxoplasma gondii is a widely distributed zoonotic parasite at the human–animal interface. However, studies simultaneously evaluating animal-associated workers and companion animals remain limited in South Korea. This multi-regional cross-sectional study aimed to estimat...

Long-term surveillance reveals weak coupling between chigger burden on Apodemus agrarius and Orientia tsutsugamushi pool positivity

Long-term vector surveillance often reports ectoparasite burden and pooled pathogen detection together, but their quantitative relationship is rarely tested. We analysed rodent-associated chigger surveillance conducted from 2018 to 2025 across five habitat strata in Yesan-si, Rep...

Tigecycline versus doxycycline for scrub typhus: a preliminary randomized trial

Abstract Background Doxycycline is the standard treatment for scrub typhus, but evidence regarding parenteral alternatives remains limited in hospitalized patients. Main body We conducted a multicenter, prospective, randomized, open-label trial in Korea. Participants were enrolle...

Spatial nonparametric Bayesian Poisson hurdle model for analyzing zero-inflated tick data

Abstract Severe fever with thrombocytopenia syndrome, an infectious tick-borne disease, has been increasingly reported in South Korea. Understanding the epidemiology of its vectors will help predict the spatio-seasonal abundance of ticks and manage future health risks related to...

Progression from carbapenemase-producing Enterobacterales colonisation to subsequent clinical isolation in a Korean regional surveillance cohort: a retrospective cohort study

Carbapenemase-producing Enterobacterales (CPE) colonisation may progress to clinical infection. We aimed to determine the incidence of and risk factors for progression from CPE colonisation to clinical isolation in a regional surveillance cohort. From the 2024 mandatory CRE surve...

Comparative analysis of associations between facility structure and air quality managers’ knowledge, attitudes, and practices by COVID-19 outbreak status in welfare facilities for persons with disabilities: a cross-sectional survey study in South Korea

Objectives: This study investigated associations between building structure and managers' knowledge, attitudes, and practices (KAP) regarding indoor air quality in welfare facilities for persons with disabilities, comparing facilities with and without coronavirus disease 2019 (CO...

Economic effectiveness of training personnel for infectious disease response and improving information systems in Republic of Korea: a cost-benefit analysis

Objectives: This study assessed the economic value of 2 major initiatives within the national infectious disease response system of the Korea Disease Control and Prevention Agency (KDCA): the Training Programs for Public Health Workforce (TPPHW) and the Infectious Disease Informa...