Korea Basic Science Institute

Harnessing Photoexcited-State Pathways in Boron Dipyrromethene for Phototheranostics and Photopolymerization

Abstract Boron dipyrromethene (BODIPY) dyes are widely recognized for their strong visible-light absorption, high fluorescence, and structural modularity. Beyond fluorescence, molecular engineering can redirect their photoexcited states toward distinct photochemical pathways, exp...

Variational Auto Encoder for automated structure segmentation of materials

Atomic-scale structural heterogeneity plays a crucial role in determining the properties of nanomaterials and complex energy systems. High-resolution STEM imaging provides critical insights into these structures, but conventional segmentation techniques often struggle with intric...

Paired cerebrospinal fluid metabolomic changes across repeated anodal transcranial direct current stimulation in Parkinson’s disease: an exploratory within-subject study

Transcranial direct current stimulation (tDCS) has been investigated as an adjunctive intervention for Parkinson’s disease (PD), but its biochemical correlates in the human central nervous system remain poorly characterized. We examined participant-level cerebrospinal fluid (CSF)...

Hybrid‐Secondary Ion Mass Spectrometry Probes Atomic‐Scale Insight Into Selective C─C Bond Cleavage in PET Upcycling

ABSTRACT Herein, we present a rapid CO 2 laser irradiation approach to stabilize Ru single‐atoms (Ru–SAs) on two‐dimensional NiO nanosheets (Ru–SA/NiO). Laser treatment (λ ≈ 10.6 µm, power ≈ 7 W) induces oxygen vacancies in NiO, promotes interfacial electron transfer from NiO to...

The anchor and the architect: Merging gene drive, membrane tethering and generative AI for next‐generation vector control

The recent success of gene drive mosquitoes suppressing malaria signals a new era in vector control. Yet, reliance on secreted, natural peptides poses risks of instability, host toxicity and resistance evolution. We propose synthesizing two transformative technologies to overcome...

A new half-life for 146Sm: Implications for lunar chronology

The timescales and mechanisms of early mantle-crust differentiation on the terrestrial planets and the Moon are often investigated using the 146 Sm- 142 Nd chronometer. Ages derived for the formation of lunar basalt source regions from this system based on the traditional 103 Ma...

An L-phenylalanine coating for holey carbon cryo-EM grids improves particle distribution

Abstract Electron cryomicroscopy (cryo-EM) enables macromolecular structure determination at near-atomic resolution, yet specimen preparation remains a critical bottleneck. In particular, the number of particles available within the ice-filled holes is often limiting, and simple...

Transcriptome-based classification in mice with ASD-risk mutations

Autism spectrum disorder (ASD) is a neurodevelopmental condition with a strong genetic component. Large-scale human genetic studies have identified >1200 ASD-risk genes. We report a sex-balanced atlas of 1008 prefrontal RNA sequencing (RNA-seq) profiles from 17 mouse lines carryi...

A systematic interactome of Saccharomyces cerevisiae SET1C expands its functional landscape and identifies candidate regulatory connections

Set1 is the catalytic subunit of SET1C or COMPASS, which methylates histone H3K4 and serves as a scaffold for the association of seven tightly bound polypeptides. We have employed yeast two-hybrid screenings to determine the interactome of Set1 and each subunit, providing a uniqu...

WDR23 prevents bone loss by promoting autophagic degradation of TRAF6 in osteoclastogenesis

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a pivotal adaptor molecule in the receptor activator of nuclear factor-κB (RANK) and its ligand (RANKL) signaling pathways, which are essential for osteoclastogenesis. In this study, we identified WD40 repeat-containin...

Probabilistic Ecological Risk Assessment of Synthetic Musk Compounds in the Han River Estuary: Integrating Multi-Year Monitoring and Explainable Machine Learning

Synthetic musk compounds (SMCs) are emerging contaminants frequently detected in aquatic environments due to their widespread use in personal care and household products. This study investigated the occurrence, environmental drivers, and ecological risks of twelve SMCs in the Han...

Graphitic Grain‐Network Nanoarchitecture for Ultrahigh‐Rate and Exceptionally Durable Potassium Ternary Intercalation

ABSTRACT Potassium–ternary graphite intercalation compounds (K + ‐T‐GICs) are promising high‐power potassium‐ion storage materials, but their low reversible capacity and poorly understood electrolyte‐dependent behavior have limited their practical viability. Herein, this sensitiv...

Doxorubicin-Incorporated Nanoparticles Composed of Ce6-Conjugated Hyaluronic Acid-b-poly(ethylene glycol) Copolymer for Overcoming Doxorubicin Resistance of Breast Cancer Cells

Oxidative stress in the tumor microenvironment, which is its own intrinsic property, is frequently utilized to deal with the drug-targeting issue in the nanoparticle drug delivery system. For this purpose, reactive oxygen species (ROS)-sensitive nanoparticles encapsulating doxoru...