Konyang University

Development and Preclinical Evaluation of Novel STK3/4 Inhibitors with Anti-Obesity Potential

Background: Obesity is associated with impaired adipocyte metabolism driven in part by mitochondrial dysfunction.Serine/ threonine-protein kinase 3 (STK3) and STK4 promote mitophagy, leading to reduced mitochondrial mass in adipose tissue.Thus, inhibition of STK3/4 represents a p...

Relative Contributions of Quinolone Resistance-Determining Region Mutations and Efflux Pump-Associated Mechanisms to Fluoroquinolone Resistance in Staphylococcus aureus Clinical Isolates and Their Associations with Virulence Gene Profiles

Background: Fluoroquinolone resistance in methicillin-resistant Staphylococcus aureus (MRSA) involves multiple mechanisms, including quinolone resistance-determining region (QRDR) mutations and efflux pump activity. However, the relationship between these resistance mechanisms an...

An Adaptive State- and Morphology-Based Four-Event Segmentation Algorithm for Sit-to-Stand-to-Sit Cycles from Wii Balance Board Load Signals: An Exploratory Comparison with Noraxon Report-Consistent IMU Timing

Sit-to-stand (STS) tests are often summarized by completion time or repetition count; however, phase-specific analysis requires reproducible operational segmentation. We developed an adaptive state- and morphology-based algorithm that identified ten internal anchors in Wii Balanc...

Periplexus versus intraplexus injection for interscalene brachial plexus block during arthroscopic rotator cuff repair: a randomized controlled trial

The optimal needle-tip position for ultrasound-guided interscalene block remains debated. This study compared surgical conditions after intraplexus and periplexus injection during arthroscopic rotator cuff repair. In this prospective, randomized, assessor-blinded, controlled stud...

Machine learning–driven decoding of maternal immune signatures in repeated pregnancy loss

Repeated pregnancy loss (RPL) is a multifactorial condition in which the underlying immunological mechanisms, particularly the disruption of maternal-fetal tolerance, remain incompletely understood. Although immune tolerance is critical for pregnancy success, the specific immune...

Extended treatment duration and recurrence in successfully treated drug-susceptible pulmonary tuberculosis with cavity on chest radiograph

Background Cavity on chest radiograph is recognized as an independent risk factor for recurrence in pulmonary tuberculosis (TB), but evidence supporting extended treatment in these patients remains limited, particularly in real-world data from Korea. Methods We performed a retros...

Development and evaluation of a social cognitive theory-based standard precautions education program for care workers in long-term care facilities: a quasi-experimental study

Abstract Background Standard precautions represent the first line of defense in preventing healthcare-associated infections. In long-term care facilities, care workers’ adherence to standard precautions practices is critical for effective infection prevention and control. Therefo...

All-trans retinoic acid suppresses CD8+ T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastoma

Terminal exhaustion of CD8⁺ T cells limits the efficacy of immune checkpoint blockade (ICB), particularly in glioblastoma, which is characterized by an immunosuppressive tumor microenvironment. Therefore, a better understanding of the regulators of terminal exhaustion could overc...

A novel stiffness-distribution-controlled hybrid locking compression plate for osteoporotic midshaft clavicle fractures: a finite element study

Abstract Background Fixation of osteoporotic midshaft clavicle fractures in elderly patients requires a careful balance between mechanical integrity and anatomical compatibility. Conventional single-diameter locking plate systems present an inherent trade-off, as larger plates pr...

Optic Neuritis in a Patient with Morning Glory Syndrome: A Case Report

Purpose: To describe a rare case of optic neuritis in a Morning glory syndrome (MGS) patient and to highlight the diagnostic challenges posed by congenital optic disc anomalies.Case summary: A 45-year-old woman presented with a 5-day history of an inferonasal visual field defect,...

Transporter Interactionsof Methoxyflavones and Their In Vivo PharmacokineticImplications

Abstract Flavonoids are widely consumed dietary polyphenols that modulate drug disposition via membrane transporters. Increasing attention has been paid to methoxyflavones (MeO-FLVs) because methoxylation can increase membrane permeability and metabolic stability, potentially ele...

Early refractive stability and predictive accuracy of a novel hydrophobic C-loop monofocal intraocular lens in eyes with normal axial length

This study aimed to evaluate the early postoperative refractive stabilization pattern and time course associated with a novel hydrophobic C-loop monofocal intraocular lens (IOL) following phacoemulsification cataract surgery. This retrospective study evaluated patients who underw...

Effects of Seat-Integrated Low-Frequency Acoustic Vibration on Muscle Mechanical Properties and Electromyographic Responses During Real-World Driving

Prolonged driving is associated with musculoskeletal loading, muscle fatigue, and discomfort, which may adversely affect driver performance and well-being. This study investigated the effects of seat-integrated low-frequency acoustic vibration on muscle mechanical properties and...