Konkuk University

AGV: a web-based visualization tool for reconstructed ancestral genomes

The ancestral genome is the genome of the common ancestor of extant species. Ancestral genome reconstruction infers evolutionary events from extant genomes to recover the genomic states of extinct ancestors. Although this approach provides a powerful framework for studying genome...

PHGDH inhibition overcomes dabrafenib resistance through metabolic rewiring in BRAF V600E anaplastic thyroid carcinoma

Abstract Dabrafenib, a BRAF kinase inhibitor, is used clinically to treat anaplastic thyroid carcinoma (ATC) harboring the BRAF V600E mutation. However, its clinical efficacy is limited due to the rapid emergence of resistance to treatment. In this study, we established a dabrafe...

Lipopolysaccharide priming confers trained immunity and enhances antiviral defense against Sendai virus via STAT1/2 signaling

Trained immunity, the functional reprogramming of innate immune cells that enhances responses to secondary challenges, represents a paradigm shift in our understanding of immune memory. We investigated whether lipopolysaccharide (LPS) priming could induce trained immunity against...

Intraoperative indocyanine green fluorescence in canine meningioma: macroscopic visualization, immediate MRI correlation, and clinical outcomes : a case series

Meningioma is the most common primary intracranial neoplasm in dogs, frequently presenting with seizures and focal neurological deficits. While indocyanine green (ICG) near-infrared (NIR) fluorescence is increasingly used in human neurosurgery, systematic data regarding the macro...