Komfo Anokye Teaching Hospital

A narrative review of oral manifestations, genotype–phenotype links, and management in pachyonychia congenita

Objective of study Pachyonychia Congenita (PC) is a rare autosomal dominant genodermatosis caused by mutations in keratin genes (KRT6A, KRT6B, KRT6C, KRT16, KRT17). Oral manifestations are seen in more than half of patients, most often as leukokeratosis, natal teeth, or laryngeal...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

NET-mediated immunothrombosis in ischemic stroke: pathobiology, biomarkers, and therapeutic targeting

Ischemic stroke is increasingly understood not as a purely thromboembolic event but as a thromboinflammatory disease in which innate immune and hemostatic pathways interact. Neutrophil extracellular traps (NETs) have emerged as potentially important mediators and biomarkers withi...

A qualitative study exploring how an Emergency Medicine leadership programme was received in Ghana

Introduction Emergency Medicine (EM) is a developing specialty in several West African countries, where practitioners are increasingly assuming leadership roles despite limited training. The EM Leaders programme, originally designed for the UK context, offers leadership training...

Aspirin use for pre-eclampsia prevention in IVF/ICSI pregnancies in Kumasi, Ghana: a prospective cohort study

Pregnancies conceived through assisted reproductive technology (ART) have a substantially elevated risk of pre-eclampsia, and international guideline classify ART as a high-risk factor warranting low-dose aspirin prophylaxis. However, data on aspirin utilisation and effectiveness...