Koltzov Institute of Developmental Biology

Delivery of transgenes into Gαo-rich subcortical structures of the mouse brain with potential applications for GNAO1 encephalopathy

Adeno-associated virus (AAV) vectors are widely used for transgene delivery into the mouse brain in preclinical studies, yet AAV methodology requires customization for each neurological disease. In this study, we aimed to identify the optimal approach for AAV-mediated transductio...

Evaluating Carniolan honey bee (Apis mellifera carnica) lines under contrasting ecological zones

This study evaluates four breeding lines of the Carniolan honey bee, Apis mellifera carnica, across distinct ecological zones of Serbia and Montenegro. The objective was to assess phenotypic, morphometric, and isoenzyme polymorphism of local populations adapted to contrasting cli...

The I130V and S229F Tropomyosin Mutations Associated With Congenital Heart Disease Disrupt Actin‐Myosin Interactions in the Atria

ABSTRACT Tropomyosin is a highly conserved α‐helical coiled‐coil protein that is involved in maintaining the structural integrity of the sarcomere and regulating contraction of striated muscle. Mutations in the TPM1 gene encoding cardiac α‐tropomyosin (Tpm1.1) are associated with...