Koch Institute for Integrative Cancer Research At MIT

Power-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowding

Abstract Genome size varies more than 10,000-fold across eukaryotes, yet how the mitotic spindle adapts to this range remains unknown. Here we show that metaphase plate width scales with genome size following a power law with an exponent of ~1/3 across eukaryotes. Comparative ana...